{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T21:33:11Z","timestamp":1774819991587,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hypopituitarism is associated with higher prevalence of cardiovascular risk factors and premature death. Furthermore, some clinical and therapeutic features of hypopituitarism have been associated with a worse prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We reviewed, retrospectively, a large series of adult patients with hypopituitarism using stringent epidemiological criteria. Prevalence, association with cardiovascular risk factors, mortality and survival have been analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Methods<\/jats:title><jats:p>Two hundred and nine adult hypopituitary patients (56\u00b79% females) from a population of 405\u00a0218 inhabitants, followed for 10\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prevalence of hypopituitarism at the end of the study was 37\u00b75\u00a0cases\/100\u00a0000 inhabitants. Incidence of hypopituitarism was 2\u00b707\u00a0cases\/100\u00a0000 inhabitants and year. Thirty\u2010two patients died during the period of the study. Standardized mortality rate (<jats:styled-content style=\"fixed-case\">SMR<\/jats:styled-content>) was 8\u00b705, higher in males (8\u00b792<jats:italic>vs<\/jats:italic>7\u00b734) and in younger patients (84\u00b793<jats:italic>vs<\/jats:italic>5\u00b726). Diagnosis of acromegaly (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7033), previous radiotherapy (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702), higher<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>(<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b704), diabetes mellitus (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b703) and cancer (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001) were associated with mortality. A lower survival was associated with older age at diagnosis, nontumoural causes, previous radiotherapy, diabetes mellitus with poor metabolic control and malignant disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prevalence of hypopituitarism was 37\u00b75 cases\/100\u00a0000 inhabitants, and annual incidence was 2\u00b707 cases\/100\u00a0000 inhabitants.<jats:styled-content style=\"fixed-case\">SMR<\/jats:styled-content>was 8 times higher in hypopituitarism than in general population and was also higher in males and younger patients. Reduced survival was significantly related to cancer, nontumoural causes of hypopituitarism, older age at diagnosis, previous radiotherapy and diabetes mellitus with poor metabolic control.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04516.x","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T03:57:18Z","timestamp":1343707038000},"page":"278-284","source":"Crossref","is-referenced-by-count":33,"title":["Epidemiology, mortality rate and survival in a homogeneous population of hypopituitary patients"],"prefix":"10.1111","volume":"78","author":[{"given":"E.","family":"Fernandez\u2010Rodriguez","sequence":"first","affiliation":[{"name":"Endocrinology Department Complejo Hospitalario Universitario de Santiago de Compostela (SERGAS) Santiago de Compostela Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Santiago de Compostela (IDIS) Universidad de Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lopez\u2010Raton","sequence":"additional","affiliation":[{"name":"Biostatistics Unit Statistics and Operations Research Department Facultad de Medicina Universidad de Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Andujar","sequence":"additional","affiliation":[{"name":"Endocrinology Department Complejo Hospitalario Universitario de Santiago de Compostela (SERGAS) Santiago de Compostela Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Santiago de Compostela (IDIS) Universidad de Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. M.","family":"Martinez\u2010Silva","sequence":"additional","affiliation":[{"name":"Biostatistics Unit Statistics and Operations Research Department Facultad de Medicina Universidad de Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Cadarso\u2010Suarez","sequence":"additional","affiliation":[{"name":"Biostatistics Unit Statistics and Operations Research Department Facultad de Medicina Universidad de Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. F.","family":"Casanueva","sequence":"additional","affiliation":[{"name":"Endocrinology Department Complejo Hospitalario Universitario de Santiago de Compostela (SERGAS) Santiago de Compostela Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Santiago de Compostela (IDIS) Universidad de Santiago de Compostela Santiago de Compostela Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER) de Fisiopatolog\u00eda Obesidad y Nutrici\u00f3n Instituto Salud Carlos III Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Bernabeu","sequence":"additional","affiliation":[{"name":"Endocrinology Department Complejo Hospitalario Universitario de Santiago de Compostela (SERGAS) Santiago de Compostela Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Santiago de Compostela (IDIS) Universidad de Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01406.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04006-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91812-O"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.12.1429"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324087"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02989.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.03070.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60673-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K06-129"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.3.1169"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00650.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1997.d01-1749.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031601"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02545.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009901707125"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02179"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1326"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0013"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb01860.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.4.1420"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-007-0018-x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.11.3897"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life\u2010tables","volume":"34","author":"Cox D.R.","year":"1972","journal-title":"Journal of the Royal Statistical Society. Series B"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-3115-3"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00337.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199907000-00004"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2008.01.009"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3181a84bde"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01320.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92892-J"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-54-2-254"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1500497"},{"key":"e_1_2_7_34_1","unstructured":"Instituto Nacional de Estad\u00edstica de Espa\u00f1a (INE). Available atwww.ine.es(Last accesed December 2011)."},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02947.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1191"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031584"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01570.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890615)63:12<2404::AID-CNCR2820631205>3.0.CO;2-3"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.05.034"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0304"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09519-3"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7160.703"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030840"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2012.04516.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2012.04516.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T19:36:16Z","timestamp":1714246576000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2012.04516.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,7]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/j.1365-2265.2012.04516.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2012.04516.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,7]]}}}