{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:16:34Z","timestamp":1783487794297,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T00:00:00Z","timestamp":1359072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>n<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> test is the gold standard to confirm the diagnosis of central precocious puberty (<jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content>); however, this compound is not always readily available. Diagnostic accuracy of subcutaneous <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>n<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> analogues tests compared to classical <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>n<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> test has not been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the diagnostic accuracy of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>riptorelin test (index test) compared to the <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>n<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> test (reference test) in girls with suspicion of <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A prospective, case\u2013control, randomized clinical trial was performed. <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> or precocious thelarche (<jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content>) was diagnosed according to maximal <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> response to <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>n<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> test and clinical characteristics during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Interventions<\/jats:title><jats:p>Forty\u2010six girls with premature breast development randomly underwent two tests: (i) intravenous Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> 100\u00a0\u03bcg, (ii) subcutaneous <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>riptorelin acetate (0\u00b71\u00a0mg\/m<jats:sup>2<\/jats:sup>, to a maximum of 0\u00b71\u00a0mg) with blood sampling at 0, 3 and 24\u00a0h for <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FSH<\/jats:styled-content> and estradiol ascertainment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Gonadotrophins and estradiol responses to <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>riptorelin test were measured by ultrasensitive assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical features were similar between <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a033) and <jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a013) groups. Using receiver operating characteristic curves, maximal <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> response (<jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>\u20103\u00a0h) under <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>riptorelin test \u22657\u00a0<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/l by immunofluorometric assay (<jats:styled-content style=\"fixed-case\">IFMA<\/jats:styled-content>) or \u22658 <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/l by electrochemiluminescence immunoassay (<jats:styled-content style=\"fixed-case\">ECLIA<\/jats:styled-content>) confirmed the diagnosis of <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> with specificity of 1\u00b700 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0\u00b775\u20131\u00b700) and sensitivity 0\u00b776 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0\u00b758\u20130\u00b789). Considering either <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>\u20103\u00a0h or maximal estradiol response at 24\u00a0h (cut\u2010off value, 295\u00a0p<jats:sc>m<\/jats:sc>), maintaining the specificity at 1\u00b700, the test sensitivity increased to 0\u00b794 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0\u00b780\u20130\u00b799) and the diagnostic efficiency to 96%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>riptorelin test had high accuracy for the differential diagnosis of <jats:styled-content style=\"fixed-case\">CPP <\/jats:styled-content><jats:italic>vs <\/jats:italic><jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content> in girls providing a valid alternative to the classical Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> test. This test also allowed a comprehensive evaluation of the pituitary\u2013ovarian axis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04517.x","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T07:29:28Z","timestamp":1343719768000},"page":"398-404","source":"Crossref","is-referenced-by-count":41,"title":["High diagnostic accuracy of subcutaneous <scp>T<\/scp>riptorelin test compared with Gn<scp>RH<\/scp> test for diagnosing central precocious puberty in girls"],"prefix":"10.1111","volume":"78","author":[{"given":"Anal\u00eda Ver\u00f3nica","family":"Freire","sequence":"first","affiliation":[{"name":"Hospital de Ni\u00f1os \u201cDr. Ricardo Guti\u00e9rrez\u201d Divisi\u00f3n de Endocrinolog\u00eda Centro de Investigaciones Endocrinol\u00f3gicas (CEDIE) Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Eugenia","family":"Escobar","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os \u201cDr. Ricardo Guti\u00e9rrez\u201d Divisi\u00f3n de Endocrinolog\u00eda Centro de Investigaciones Endocrinol\u00f3gicas (CEDIE) Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirta Graciela","family":"Gryngarten","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os \u201cDr. Ricardo Guti\u00e9rrez\u201d Divisi\u00f3n de Endocrinolog\u00eda Centro de Investigaciones Endocrinol\u00f3gicas (CEDIE) Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Josefina","family":"Arcari","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os \u201cDr. Ricardo Guti\u00e9rrez\u201d Divisi\u00f3n de Endocrinolog\u00eda Centro de Investigaciones Endocrinol\u00f3gicas (CEDIE) Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Gabriela","family":"Ballerini","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os 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