{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:16:32Z","timestamp":1763036192482},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T00:00:00Z","timestamp":1165363200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Otolaryngology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> To determine the effects of a total laryngectomy on the swallow and subsequent quality of life in head and neck cancer patients.<\/jats:p><jats:p><jats:bold>Design:\u2002<\/jats:bold> Cross\u2010sectional single centre cohort study.<\/jats:p><jats:p><jats:bold>Setting:\u2002<\/jats:bold> Head and Neck Oncology Unit, Tertiary Referral Unit.<\/jats:p><jats:p><jats:bold>Patients:\u2002<\/jats:bold> Sixty\u2010two patients who underwent total laryngectomy at our centre participated in the study.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Subjects were stratified by age, sex, tumour stage, other procedures such as myotomy and nerve re\u2010implantation. Pharyngectomy, glossectomy, flap reconstruction, neck dissection and previous radio\u2010 and chemotherapy were also assessed to see if they affected swallow and subsequent quality of life. Main outcome was measured using the MD Anderson Dysphagia Inventory questionnaire.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Responses were received from 46 males and 16 females (response rate of 80.5%) with a mean age of 64.7\u2003years (SD 9.4). Median follow\u2010up in patients was 90\u2003months (range 1\u2013276). The mean MD Anderson Dysphagia Inventory total score in our series of patients was 77.7 (SD 16.6). MD Anderson Dysphagia Inventory global score was 79.4 (SD 22.6), Emotional score was 77.7 (SD 17.8), Functional score 81.3 (SD 15.9) and Physical score was 74.1(SD 18). Statistically significant differences were seen between the emotional scores of glossectomised and non\u2010glossectomised patients (Mann Whitney, <jats:italic>P<\/jats:italic>\u2003=\u20030.04). No significant correlation was seen between the subscale scores and the remaining treatment variables such as age, gender, site, tumour stage, myotomy, nerve implantation, radiotherapy, reconstruction and major complications.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> This questionnaire study is the largest of its type to assess the swallow of patients who have undergone laryngectomy at a single centre. The overall result confirmed that most patients had a subjectively good swallow. Only glossectomy and the method of PE segment closure were shown to significantly affect swallowing outcomes following surgery. We recommend further work especially prospective studies pre and post surgery using this or similarly validated instruments to fully assess swallow in the laryngectomy population.<\/jats:p>","DOI":"10.1111\/j.1365-2273.2006.01335.x","type":"journal-article","created":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T18:02:20Z","timestamp":1165428140000},"page":"525-530","source":"Crossref","is-referenced-by-count":19,"title":["Questionnaire analysis of the swallowing\u2010related outcomes following total laryngectomy"],"prefix":"10.1111","volume":"31","author":[{"given":"R.","family":"Kazi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Venkitaraman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.M.","family":"Nutting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Rhys\u2010Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.J.","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,6]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106133242402"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.13.890"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/014556130108001217"},{"key":"e_1_2_8_5_2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0030-6665(20)30239-5","article-title":"Speech outcomes after laryngeal cancer management","volume":"30","author":"Simpson C.B.","year":"1997","journal-title":"Otolaryngol. Clin."},{"key":"e_1_2_8_6_2","unstructured":"American Cancer Society. (2002)Cancer Facts and Figures. Available athttp:\/\/www.cancer.org. Accessed December 26 2003"},{"key":"e_1_2_8_7_2","first-page":"870","article-title":"The development and validation of a dysphagia specific quality of life questionnaire for patients with head and neck cancer: the M.D. Anderson Dysphagia Inventory","volume":"127","author":"Chen A.Y.","year":"2001","journal-title":"Arch Otol. Head Neck Surg."},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(200003)22:2<120::AID-HED3>3.0.CO;2-U"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880160404"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1044\/jslhr.4304.1011"},{"key":"e_1_2_8_11_2","first-page":"571","volume-title":"Principles and Practice of Head and Neck Oncology","author":"Rhys Evans P.H.","year":"2003"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200306000-00001"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200408000-00008"},{"key":"e_1_2_8_14_2","first-page":"362","article-title":"Self\u2010assessment of the dysphagia effect on the quality of life in patients after a partial laryngectomy due to cancer initially located in the supraglottic area","volume":"111","author":"Strek P.","year":"2005","journal-title":"Pol. 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