{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:58:25Z","timestamp":1792598305851,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,3,22]],"date-time":"2005-03-22T00:00:00Z","timestamp":1111449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> Fine needle aspiration cytology (FNAC) in combination with radiological examination has recently gained clinical recognition for evaluating skeletal lesions. We evaluated our experience with the use of FNA in diagnosing bone lesions with emphasis on areas of difficulty and limitations.<\/jats:p><jats:p><jats:bold>Materials and Methods:\u2002<\/jats:bold> Over a period of 5\u2003years FNA was performed in 66 cases of bone lesions. Aspirations were done by cytopathologists using 22\u2010gauge needle. Out of 66 cases unsatisfactory aspirate was obtained in 12 cases. Cytohistological correlation was available in 19 cases.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Adequate aspirates were categorized into neoplastic (27 cases) and non\u2010neoplastic (27 cases) lesions. Of the 27neoplastic aspirates, 20 were malignant (12 primary, 8 metastatic deposits) and 7 were benign. In the malignant group osteosarcoma was correctly diagnosed in 3 cases while other 3 were labeled as sarcoma NOS because of lack of osteoid. Metastatic deposits were sub\u2010typed in 6 cases; from renal cell carcinoma (3 cases), proststic adenocarcinoma, follicular carcinoma thyroid, and squamous cell carcinoma. Neoplastic group comprised of 6 cases of cysts and 21 cases of chronic osteomyelitis. Thirteen cases were diagnosed as tuberculous osteomyelitis.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> FNA is a frequent indication in metastases in the bone where distinct cytologic features can even identify an unknown primary. However, diagnosis of primary tumours of the bone is limited by precise subtyping of the tumours. FNA has emerged as a cost effective tool for initial diagnosis of both neoplastic and non\u2010neoplastic lesions of the bone.<\/jats:p>","DOI":"10.1111\/j.1365-2303.2004.00200.x","type":"journal-article","created":{"date-parts":[[2006,7,8]],"date-time":"2006-07-08T00:00:56Z","timestamp":1152316856000},"page":"59-64","source":"Crossref","is-referenced-by-count":36,"title":["Fine needle aspiration cytology in the diagnosis of bone lesions"],"prefix":"10.1111","volume":"16","author":[{"given":"U.","family":"Handa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Mohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bhardwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,3,22]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0339(200007)23:1<59::AID-DC14>3.0.CO;2-X"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970625)81:3<148::AID-CNCR4>3.0.CO;2-N"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/106.5.561"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000331962"},{"key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"522","DOI":"10.2106\/00004623-198365040-00015","article-title":"Fine needle aspiration biopsy of bone","volume":"65","author":"El Khouty GY","year":"1983","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_7_7_2","first-page":"588","article-title":"Cytodiagnosis of bone and soft tissue lesions by fine needle aspiration","volume":"27","author":"Feldman PS","year":"1983","journal-title":"Acta Cytol"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197902)43:2<735::AID-CNCR2820430250>3.0.CO;2-H"},{"key":"e_1_2_7_9_2","first-page":"139","article-title":"Aspiration (puncture or needle) biopsy in bone lesions","volume":"54","author":"Schajowitz F","year":"1976","journal-title":"Recent Results Cancer Res"},{"key":"e_1_2_7_10_2","first-page":"77","article-title":"Fine needle aspiration cytology of primary bone lesions","volume":"31","author":"Layfield LJ","year":"1987","journal-title":"Acta Cytol"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200004000-00011"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/111.5.632"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000225)90:1<47::AID-CNCR7>3.0.CO;2-T"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900415)65:8<1847::AID-CNCR2820650831>3.0.CO;2-Q"},{"key":"e_1_2_7_15_2","first-page":"444","volume-title":"Handbook of Fine Needle Aspiration Biopsy Cytology","author":"Kline TS.","year":"1998"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000332680"},{"key":"e_1_2_7_17_2","first-page":"323","volume-title":"Manual and Atlas of Fine Needle Aspiration Cytology","author":"Orell SR","year":"2000"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000331829"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10120"},{"key":"e_1_2_7_20_2","first-page":"435","article-title":"Scapulohumeral tuberculosis diagnosed by fine needle aspiration cytology","volume":"42","author":"Sahoo M","year":"1998","journal-title":"Acta Cytol"},{"key":"e_1_2_7_21_2","first-page":"224","article-title":"Diagnosis of cryptococcal osteomyelitis by fine needle aspiration cytology: a case report","volume":"26","author":"Ganjei P","year":"1982","journal-title":"Acta Cytol"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198062080-00007"},{"key":"e_1_2_7_23_2","first-page":"538","article-title":"Fine needle aspiration cytology of tuberculosis of the lumbar vertebrae (Pott's disease)","volume":"30","author":"Silverman JF","year":"1986","journal-title":"Acta Cytol"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10479"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2303.2004.00200.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2303.2004.00200.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T23:12:49Z","timestamp":1697238769000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2303.2004.00200.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,22]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["10.1111\/j.1365-2303.2004.00200.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2303.2004.00200.x","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3,22]]}}}