{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:19:45Z","timestamp":1770823185130,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,16]],"date-time":"2006-01-16T00:00:00Z","timestamp":1137369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p><jats:bold>Background and aims:\u2002<\/jats:bold> Endoscopic ultrasound\u2010guided fine needle aspiration (EUS\u2010FNA) has a diagnostic accuracy of 70\u201390%, depending on the site under evaluation. In order to improve EUS\u2010guided tissue sampling a novel 19\u2010gauge trucut\u2010type needle has been designed to obtain core biopsies during EUS. We prospectively evaluated the safety and accuracy of EUS\u2010FNA alone versus combined EUS\u2010FNA and trucut needle biopsy (TNB) in patients referred to our Unit over a 3\u2010year period.<\/jats:p><jats:p><jats:bold>Patients and methods:\u2002<\/jats:bold> A total of 159 patients underwent EUS\u2010FNA alone (lesions &lt;2\u2003cm) or the combination of both sampling modalities (lesions \u22652\u2003cm). The adequacy of sampling, sensitivity, specificity and overall accuracies of EUS\u2010FNA or EUS\u2010TNB alone and combined EUS\u2010FNA\/TNB were determined.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Adequate samples were obtained by EUS\u2010FNA, EUS\u2010TNB and EUS\u2010FNA\/TNB in 91%, 88% and 97% of patients, respectively. From the pancreas (<jats:italic>n<\/jats:italic>\u2003=\u200383), adequate samples were obtained by FNA in 94% and by TNB in 81%, compared with 87% and 92% from non\u2010pancreatic sites (<jats:italic>n<\/jats:italic>\u2003=\u200376), respectively. The combination of both techniques resulted in more adequate samples from non\u2010pancreatic cases than EUS\u2010FNA alone (<jats:italic>P<\/jats:italic>\u2003=\u20030.044). The specificity was 100%. Overall accuracy for EUS\u2010FNA alone was 77%, for EUS\u2010TNB alone 73% and for EUS\u2010FNA\/TNB 91% (<jats:italic>P<\/jats:italic>\u2003=\u20030.008). For pancreatic sampling, the accuracy of EUS\u2010FNA alone was 77%, for EUS\u2010TNB alone 56% and for EUS\u2010FNA\/TNB 83%. For non\u2010pancreatic sampling, the accuracy for EUS\u2010FNA alone was 78%, for EUS\u2010TNB alone 83% and for EUS\u2010FNA\/TNB 95% (<jats:italic>P<\/jats:italic>\u2003=\u20030.006). The complication rate was 0.6%.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Combined EUS\u2010FNA\/TNB for lesions \u22652\u2003cm improves adequacy of sampling and diagnostic accuracy compared with either technique alone and is safe.<\/jats:p>","DOI":"10.1111\/j.1365-2303.2006.00313.x","type":"journal-article","created":{"date-parts":[[2006,1,16]],"date-time":"2006-01-16T16:10:40Z","timestamp":1137427840000},"page":"27-33","source":"Crossref","is-referenced-by-count":121,"title":["Endoscopic ultrasound\u2010guided tissue sampling by combined fine needle aspiration and trucut needle biopsy: a prospective study"],"prefix":"10.1111","volume":"17","author":[{"given":"J.","family":"Wittmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Kocjan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. N.","family":"Sgouros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Deheragoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. P.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,16]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70164-1"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(04)02393-4"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00052-6"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.117764"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(97)70266-9"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.114783"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)00031-4"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.219.1.r01ap44252"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-6-200103200-00010"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07472.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(03)02863-3"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(02)70193-4"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2003.49"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-814316"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(03)02538-0"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(04)00969-1"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(04)01529-9"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.112841"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(04)01885-1"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(02)70181-8"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2303.2006.00313.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2303.2006.00313.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T21:51:07Z","timestamp":1697233867000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2303.2006.00313.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,16]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1111\/j.1365-2303.2006.00313.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2303.2006.00313.x","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,16]]}}}