{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:39:44Z","timestamp":1792147184725,"version":"4.4.0"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,9,8]],"date-time":"2006-09-08T00:00:00Z","timestamp":1157673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> The aim of this study was to compare the cytological changes in skin, lymph nodes, liver and bone marrow in patients with lepromatous leprosy.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Skin lesion, lymph node, liver and bone marrow aspirates were analysed. May\u2013Grunwald\u2013Giemsa (MGG) and Ziehl\u2013Neelsen (Z\u2013N) stains were employed. Comparative cytomorphology was studied.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Twenty patients with lepromatous leprosy were studied. Lepra cells (LC) predominated in the skin aspirates of 12 patients with lepromatous leprosy (LL), lymphocytes accompanied LC in eight patients with borderline\u2010lepromatous (BL) leprosy. Three patients of LL leprosy and two of BL leprosy in type 2 reaction additionally had numerous neutrophils. Two patterns of lymph node aspirates were seen: partial replacement with few LC in a reactive lymphoid background (10), complete replacement with either only LC or LC in a background of degenerating neutrophils (10), the latter a feature of type 2 reaction. Liver aspiration was performed in seven patients and of bone marrow in eight patients. Occasional LC were present in five liver\u2010aspirated patients, steatosis and Kupffer cell hyperplasia in four patients, and myelopoiesis in two patients. Bone marrow smears invariably had occasional LC and a relative increase in mature plasma cells; sea\u2010blue histiocytes were seen in six patients.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Lepra cells predominated in skin and lymph node aspirates with complete replacement. In comparison, liver, bone marrow and lymph node aspirates with partial replacement were dominated by a preponderance of cells native to these organs with only few or occasional LC.<\/jats:p>","DOI":"10.1111\/j.1365-2303.2006.00323.x","type":"journal-article","created":{"date-parts":[[2006,9,8]],"date-time":"2006-09-08T08:47:21Z","timestamp":1157705241000},"page":"257-261","source":"Crossref","is-referenced-by-count":15,"title":["Comparative cytomorphology of skin, lymph node, liver and bone marrow in patients with lepromatous leprosy<sup>1<\/sup>"],"prefix":"10.1111","volume":"17","author":[{"given":"N.","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lakra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. K.","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. N.","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,8]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"53","article-title":"A study of one hundred and fifty autopsies on cases of leprosy","volume":"5","author":"Mitsuda K","year":"1937","journal-title":"Int J Lepr"},{"key":"e_1_2_5_3_2","first-page":"377","article-title":"Pathological findings on peripheral nerve, lymph node, and visceral organs of leprosy","volume":"52","author":"Tze\u2010Chun L","year":"1984","journal-title":"Int J Lepr"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000333945"},{"key":"e_1_2_5_5_2","volume-title":"A Guide to Leprosy Control","author":"World Health Organization","year":"1988"},{"key":"e_1_2_5_6_2","first-page":"255","article-title":"Classification of leprosy according to immunity: a five group system","volume":"34","author":"Ridley DS","year":"1966","journal-title":"Int J Lepr"},{"key":"e_1_2_5_7_2","first-page":"145","article-title":"Fine needle aspiration cytology of lepromatous leprosy","volume":"69","author":"Singh N","year":"1998","journal-title":"Lepr Rev"},{"key":"e_1_2_5_8_2","first-page":"570","article-title":"Bacillaemia in lepra reaction: its correlation with liver pathology","volume":"55","author":"Zawar PB","year":"1983","journal-title":"Lepr Ind"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.5935\/0305-7518.19690016"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000331290"},{"key":"e_1_2_5_11_2","first-page":"189","article-title":"Hansen's disease (leprosy) diagnosis by aspiration biopsy of lymph nodes","volume":"30","author":"Cavett JR","year":"1986","journal-title":"Acta Cytol"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840110412"},{"key":"e_1_2_5_13_2","first-page":"224","volume-title":"Pathology of Liver","author":"Simson IW","year":"1987"},{"key":"e_1_2_5_14_2","first-page":"1346","volume-title":"Clinical Hematology","author":"Wintrobe MM","year":"1981"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2303.2006.00323.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2303.2006.00323.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T22:06:54Z","timestamp":1697234814000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2303.2006.00323.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,8]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1111\/j.1365-2303.2006.00323.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2303.2006.00323.x","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,8]]}}}