{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:27:43Z","timestamp":1756463263642},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,9,8]],"date-time":"2006-09-08T00:00:00Z","timestamp":1157673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> To assess the correlation between cytological diagnoses and histological subtypes of fibroadenoma (FA) and to clarify the cytological features of a specific group of FA displaying variable features similar to fibrocystic disease (mastopathic type, MFA), and to evaluate the significance of this subtype in cytological diagnosis.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A review of 141 cases of histologically proven FA was performed. We re\u2010classified them into four subtypes according to Kinoshita's criteria [<jats:italic>Jpn J Breast Cancer<\/jats:italic><jats:bold>6<\/jats:bold> (1991) 377] and further selected 92 cases for which both fine needle aspiration (FNA) smears and histological specimens were available. Among them, 18 cases of MFA and their cytological smears were selected for the present study.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> There was significant correlation between MFA and cytological diagnosis of \u2018indeterminate\u2019 or \u2018suspicious for malignancy\u2019 (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01). Although no false\u2010positive diagnosis was experienced in our series, 56% of the MFAs (10\/18) had cytological diagnoses of indeterminate or were included in the category \u2018suspicious for malignancy\u2019. Smears from MFA revealed high cellularity (9\/18 smears had more than 10 epithelial clusters each composed of more than 50 cells), presence of cellular discohesiveness (13\/18, 72.2%), but only mild nuclear atypia (5\/18, 27.8%). Anisonucleosis was present in fewer than half the cases and no apparent condensed chromatin was identified.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> We highlight the significance of subclassification of MFA in aspiration cytology of breast. MFA had a significantly higher chance of falling into the \u2018suspicious for malignancy\u2019 or \u2018indeterminate\u2019 diagnostic category in aspiration cytology. It might be a diagnostic challenge for cytopathologist to identify this subtype of FA in FNA smears.<\/jats:p>","DOI":"10.1111\/j.1365-2303.2006.00333.x","type":"journal-article","created":{"date-parts":[[2006,9,8]],"date-time":"2006-09-08T08:47:21Z","timestamp":1157705241000},"page":"233-238","source":"Crossref","is-referenced-by-count":11,"title":["Mastopathic fibroadenoma of the breast: a pitfall of aspiration cytology"],"prefix":"10.1111","volume":"17","author":[{"given":"I.","family":"Mori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kakudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,8]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"188","volume-title":"The Breast","author":"Page LD","year":"2004"},{"key":"e_1_2_5_3_2","first-page":"86","volume-title":"World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of the Breast and Female Genital Organs","author":"Bellocq JP","year":"2003"},{"key":"e_1_2_5_4_2","first-page":"898","article-title":"The spectrum of the \u2018\u2018gray zone\u2019\u2019 in breast cytology. A review of 186 cases of atypical and suspicious cytology","volume":"38","author":"Al\u2010Kaisi N","year":"1994","journal-title":"Acta Cytol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000331149"},{"key":"e_1_2_5_6_2","first-page":"530","article-title":"Fine needle aspiration diagnosis of a breast fibroadenoma with multinucleated stromal giant cells","volume":"43","author":"Lanjewar DN","year":"1999","journal-title":"Acta Cytol"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840080623"},{"key":"e_1_2_5_8_2","first-page":"377","article-title":"Fibroadenoma of the breast: review of histopathological subtypes and its changes in 1968 and 1988\u20131989","volume":"6","author":"Kinoshita S","year":"1991","journal-title":"Jpn J Breast Cancer"},{"key":"e_1_2_5_9_2","first-page":"170","volume-title":"Rosen's Breast Pathology","author":"Rosen PP","year":"2001"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199407073310103"},{"key":"e_1_2_5_11_2","first-page":"395","article-title":"Mastopathic type of fibroadenoma","volume":"4","author":"Sakamoto G","year":"2001","journal-title":"Pathol Clin"},{"key":"e_1_2_5_12_2","first-page":"27","volume-title":"General Rules for Clinical and Pathological Recording of Breast Cancer","author":"Japanese Breast Cancer Society","year":"2004"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000332692"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/00313028709103889"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/98.2.155"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000328533"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2303.2006.00333.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2303.2006.00333.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T22:06:38Z","timestamp":1697234798000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2303.2006.00333.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,8]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1111\/j.1365-2303.2006.00333.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2303.2006.00333.x","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,8]]}}}