{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:33:33Z","timestamp":1760297613248},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,5,23]],"date-time":"2006-05-23T00:00:00Z","timestamp":1148342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p><jats:bold>Aim:\u2002<\/jats:bold> To validate the method of rapid screening (RS) in the detection of cervical lesions and false\u2010negative results as well as in quality control of cytotechnologist performance.<\/jats:p><jats:p><jats:bold>Material and methods:\u2002<\/jats:bold> The RS method was validated on Papanicolaou\u2010stained and initially conventionally analysed vaginal, cervical and endocervical (VCE) smears collected in an opportunistic programme for the detection of cervical carcinoma. The study included 3680 VCE smears from the Department of Gynaecologic Cytology, University Department of Gynaecology and Obstetrics, Zagreb University Hospital Center, Zagreb and from the Department of Clinical Cytology, Osijek University Hospital, Osijek. Histologically verified abnormal findings accounted for 10% of the study samples. Thirteen cytotechnologists, with no previous experience in RS, performed the test. Each slide was examined using the \u2018step\u2019 technique for 1.5\u2003minutes, the findings were classified as negative or abnormal, and the abnormal ones were also classified according to differential cytological diagnosis. The results were compared with those obtained on initial screening. Abnormal findings from a group of initially negative findings were reanalysed using conventional methods to make definitive cytological diagnosis.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> RS yielded a sensitivity of 83.7%, specificity of 93.7%, positive predictive value of 62.4%, negative predictive value of 97.9% and diagnostic accuracy of 92.6%. Relative to the initial abnormal differential cytological diagnosis, the diagnostic value of RS increased with lesion severity [54.8%, 68.0% and 91.3% for cervical intraepithelial neoplasia (CIN) I, CIN II and CIN III respectively]. RS detected 38 additional positive findings; 94.2% of these were atypical squamous cells of undetermined significance (ASCUS)\/abnormal glandular cells undetermined significance (AGUS) and CIN I. The rate of additional positive findings was 1.14% (38\/3135). The false\u2010negative rate of initial screening was 9.4% (38\/406), and individual cytotechnologist sensitivity was 60.0\u2013100.0%.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> RS could be introduced as an efficient method of quality control to improve the sensitivity of cytological screening as well as for quality control of cytotechnologist performance.<\/jats:p>","DOI":"10.1111\/j.1365-2303.2006.00367.x","type":"journal-article","created":{"date-parts":[[2006,5,23]],"date-time":"2006-05-23T10:21:48Z","timestamp":1148379708000},"page":"121-126","source":"Crossref","is-referenced-by-count":9,"title":["Rapid cervicovaginal smear screening: method of quality control and assessing individual cytotechnologist performance"],"prefix":"10.1111","volume":"17","author":[{"given":"M.","family":"Pajtler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Audy\u2010Jurkovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"\u0160kopljanac\u2010Ma\u010dina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Antulov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bari\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Mili\u010di\u0107\u2010Juhas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,23]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Committee on Registration and Licensure: Certification of Cytology Laboratories","author":"International Academy of Cytology","year":"1970"},{"key":"e_1_2_6_3_2","volume-title":"The Efficiency of Vaginal and Cervical Smears","author":"Simon TR","year":"1957"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.1991.tb00504.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.1993.tb00072.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.11.1002"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.1997.tb00588.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.1995.tb00453.x"},{"key":"e_1_2_6_9_2","first-page":"1323","article-title":"Partial rescreening as a quality assurance method","volume":"40","author":"Faraker CA.","year":"1996","journal-title":"Acta Cytol"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.1995.tb00485.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000332451"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0339(200103)24:3<219::AID-DC1045>3.0.CO;2-Z"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000330873"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.1998.00117.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000331974"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000328615"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10921"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.2001.00340.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2004.00141.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.1998.00138.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.2003.00111.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.1998.00136.x"},{"key":"e_1_2_6_23_2","volume-title":"Achievable Standards. Benchmarks for Reporting and Criteria for Evaluating Cervical Cytopathology","author":"NHSCP","year":"1995"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.49.7.587"},{"key":"e_1_2_6_25_2","first-page":"711","article-title":"Characteristics of false\u2010negative smears tested in the normal screening situation","volume":"36","author":"Bosch MM","year":"1992","journal-title":"Acta Cytol"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.52.5.358"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.1995.tb00484.x"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.46.8.700"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/111.4.517"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2004.00134.x"},{"key":"e_1_2_6_31_2","first-page":"3024","article-title":"Partial re\u2010screening of all negative smears. A method of quality control of pathology department concerning smear screening against cervix cancer","volume":"21","author":"Jensen ML","year":"2000","journal-title":"Ugeskr Laeger"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1080\/003130299104765"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.1997.tb00589.x"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.2003.00062.x"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.2002.00410.x"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2303.2006.00367.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2303.2006.00367.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T23:42:32Z","timestamp":1697240552000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2303.2006.00367.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,23]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1111\/j.1365-2303.2006.00367.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2303.2006.00367.x","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,23]]}}}