{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:42:49Z","timestamp":1791229369403,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T00:00:00Z","timestamp":1164585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> The aim of this study was to evaluate the inter\u2010laboratory reproducibility for atypical glandular cells (AGC) (The Bethesda System (TBS) 2001) of the laboratories involved in the screening programmes in Italy.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A set of 35 selected slides were circulated among 167 laboratories involved in local population\u2010based cervical screening programmes. Each laboratory provided one single diagnosis per smear. The smears were read blind to the original diagnosis and to the diagnoses provided by other laboratories. A \u2018majority\u2019 diagnosis was defined for each case and assumed as the reference standard. The diagnosis provided from each laboratory was compared with the majority diagnosis.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> According to the majority report the 35 slides in the set were classified as negative in nine cases, AGC in eight, adenocarcinoma in eight, and squamous lesion or squamous\u2003+\u2003glandular lesion in 10. The crude agreement between all pairs of laboratories was 49.43%. <jats:italic>K<\/jats:italic>\u2010values were 0.46, 0.21, 0.34, 0.36 and 0.32 for negative, AGC\/AIS (adenocarcinoma <jats:italic>in situ<\/jats:italic> of endocervix), AdenoCa, Sq\/Sq\u2003+\u2003Gl and all reporting categories respectively. Concordance according to overall <jats:italic>K<\/jats:italic> was moderate to substantial in 77% of the participating laboratories.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The present study shows that the AGC category is not easily reproducible. The data confirmed the importance, in a screening scenario, of AGC\/AIS diagnoses, but also presented difficulties in differentiating between the two diagnoses. In addition to the results obtained from the circulation of the slides, laboratories which had annually a low number of cervical smears were able to gain experience focused on particular morphological pictures.<\/jats:p>","DOI":"10.1111\/j.1365-2303.2006.00372.x","type":"journal-article","created":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T19:52:31Z","timestamp":1164657151000},"page":"353-360","source":"Crossref","is-referenced-by-count":23,"title":["Interlaboratory reproducibility of atypical glandular cells of undetermined significance: a national survey"],"prefix":"10.1111","volume":"17","author":[{"given":"M.","family":"Confortini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Di Bonito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Carozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Ghiringhello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Montanari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Parisio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Prandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the GISCi Working Group for Cervical Cytology","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04646-8"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980209)75:4<536::AID-IJC8>3.0.CO;2-U"},{"key":"e_1_2_6_4_2","first-page":"171","article-title":"Human papillomavirus and long\u2010term contraceptive use increase the risk of adenocarcinoma in situ of the cervix","volume":"10","author":"Madeleine MM","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5826"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601754"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0339(200008)23:2<127::AID-DC13>3.0.CO;2-I"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/107.1.30"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/107.3.299"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1001\/jama.1992.03480140014005","article-title":"The Bethesda System for reporting cervical\/vaginal cytologic diagnoses, Report of the 1991 Bethesda Workshop","volume":"267","author":"National Cancer Institute Workshop","year":"1992","journal-title":"JAMA"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.2003.00061.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/001316446002000104"},{"key":"e_1_2_6_14_2","first-page":"323","article-title":"Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit","volume":"72","author":"Cohen J","year":"1968","journal-title":"Psychol Bull"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20473"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20474"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.1998.00220.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.11.1500"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3889-6_7"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00128360-200504000-00001"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2303.2006.00372.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2303.2006.00372.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:35:32Z","timestamp":1697416532000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2303.2006.00372.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,27]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1111\/j.1365-2303.2006.00372.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2303.2006.00372.x","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,27]]}}}