{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:32:39Z","timestamp":1770823959754,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,5,3]],"date-time":"2007-05-03T00:00:00Z","timestamp":1178150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p><jats:bold>Objective:\u2002<\/jats:bold> Common bile duct (CBD) brushings have been recognized as a technique of moderate sensitivity and high specificity in identifying carcinoma of the ampulla and pancreatico\u2010biliary regions. This study evaluated the increase in sensitivity of this technique using the ThinPrep<jats:sup>\u00ae<\/jats:sup> technique of specimen preparation when compared with conventional cytology smears.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A total of 113 bile duct brushings were included in the study (38 conventional smears and 75 slides prepared using the ThinPrep<jats:sup>\u00ae<\/jats:sup> technique). All slides were reviewed by one cytologist. Five categories of reporting were used: <jats:italic>inadequate<\/jats:italic>, <jats:italic>negative<\/jats:italic>, <jats:italic>atypia<\/jats:italic>, <jats:italic>suspicious<\/jats:italic> and <jats:italic>malignant<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The <jats:italic>inadequate<\/jats:italic> category of reporting disappeared in the ThinPrep<jats:sup>\u00ae<\/jats:sup> group with improved specimen fixation and preparation and hence reduced artefact. Sensitivity of diagnosis of malignancy increased from 39% in conventional smears to 53% in the ThinPrep<jats:sup>\u00ae<\/jats:sup> group. Specificity, positive and negative predictive values and accuracy were 100%, 100%, 60% and 68% for conventional smears and were 100%, 100%, 60% and 72%, respectively, for ThinPrep<jats:sup>\u00ae<\/jats:sup> specimens.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> ThinPrep<jats:sup>\u00ae<\/jats:sup> technique was associated with increased sensitivity of diagnosis, in part due to improved specimen fixation and reduced artefact. Cytology of bile duct brushings is an important diagnostic tool for sites from which it can be difficult to obtain a histology biopsy. It may therefore provide the only opportunity for tissue diagnosis of carcinoma from these sites, hence the importance of optimizing sensitivity.<\/jats:p>","DOI":"10.1111\/j.1365-2303.2007.00447.x","type":"journal-article","created":{"date-parts":[[2007,5,9]],"date-time":"2007-05-09T05:05:00Z","timestamp":1178687100000},"page":"225-233","source":"Crossref","is-referenced-by-count":17,"title":["Bile duct brushings cytology \u2013 improving sensitivity of diagnosis using the ThinPrep<sup>\u00ae<\/sup> technique: a review of 113 cases"],"prefix":"10.1111","volume":"18","author":[{"given":"M. M.","family":"Sheehan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ravindran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"McAteer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,5,3]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2004.00133.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.5858\/2000-124-0387-AOFNDO","article-title":"Analysis of false\u2010negative diagnoses on endoscopic brush cytology of biliary and pancreatic duct strictures","volume":"124","author":"Logrono R","year":"2000","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"712","DOI":"10.5858\/1999-123-0712-DAACUO","article-title":"Diagnostic accuracy and clinical utility of endoscopic bile duct brushing in the evaluation of biliary strictures","volume":"123","author":"Trent V","year":"1999","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199704)16:4<358::AID-DC11>3.0.CO;2-J"},{"key":"e_1_2_5_6_2","first-page":"498","article-title":"Brush cytology of the extrahepatic biliary tract: comparison of cytological features of adenocarcinoma and benign biliary strictures","volume":"8","author":"Cohen MB","year":"1995","journal-title":"Mod Pathol"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840180618"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10414"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326431"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10267"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2004.00129.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21842"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0956-5507.2003.00097.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11481"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.6.449"},{"key":"e_1_2_5_16_2","first-page":"11","article-title":"Accuracy and morphologic aspects of pancreatic and biliary duct brushings","volume":"39","author":"Layfield LJ","year":"1995","journal-title":"Acta Cytol"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199605)14:4<334::AID-DC12>3.0.CO;2-L"},{"key":"e_1_2_5_18_2","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1080\/00365521.1975.12097055","article-title":"Endoscopic retrograde brush cytology (ERBC) of the biliary tree and pancreatic ducts","volume":"10","author":"Osnes M","year":"1975","journal-title":"Scand J Gastroenterol"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0339(200007)23:1<6::AID-DC2>3.0.CO;2-F"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20192"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.05.010"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.07.006"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2303.2007.00447.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2303.2007.00447.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T13:29:26Z","timestamp":1697203766000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2303.2007.00447.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,3]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1111\/j.1365-2303.2007.00447.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2303.2007.00447.x","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,3]]}}}