{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:57:37Z","timestamp":1789581457400,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,11,9]],"date-time":"2010-11-09T00:00:00Z","timestamp":1289260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>E. L. Moss, A. Moran, G. Douce, J. Parkes, R. W. Todd and C. E. W. Redman<\/jats:p><jats:p> <jats:bold>Cervical cytology\/histology discrepancy: a 4\u2010year review of patient outcome<\/jats:bold> <\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> To investigate the diagnosis, review and management of women identified as having a cytology\/histology discrepancy.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> A review of all patients diagnosed with a discrepancy between referral smear and cervical histology was performed between January 2003 and December 2004. Cases were followed for a minimum of 4\u2003years and patient management and outcome reviewed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> A significant discrepancy was identified in 79 cases, 0.1% of all smears (<jats:italic>n<\/jats:italic>\u2003=\u200380\u2003926) analysed during the study period. A discrepancy between cytology and histology, obtained from large loop excision of the transformation zone (LLETZ), was confirmed by multidisciplinary review in 42 cases (53.2%). In 37 cases (46.8%) the cytological and\/or histological diagnosis was revised; the cytology was significantly more likely than the histology to be amended (chi square <jats:italic>P<\/jats:italic>\u2003=\u20030.005), most often because cytology had been overcalled. Of the confirmed discrepancy cases, 33 (78.6%) were due to high\u2010grade squamous cell or glandular abnormalities on cytology with a negative, inflammatory or human papillomavirus (HPV) infection on histology (HGC\/NH). HGC\/NH cases were managed by cytological follow\u2010up in 29 (87.9%), of which 72.4% of the smears were negative when performed at least 6\u2003months post\u2010excision. During the 4\u2010year follow\u2010up period six women with a confirmed HGC\/NH underwent a repeat cervical excision (hysterectomy or LLETZ), and of these, HPV effect was seen in two cases but no cervical intraepithelial neoplasia was detected in any of the histological specimens.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Cytology overcall was responsible for the majority of cytology\/histology discrepancies. A confirmed discrepancy is not an indication for a further excisional biopsy but follow\u2010up is essential because a small percentage of patients may have disease that has been missed.<\/jats:p>","DOI":"10.1111\/j.1365-2303.2010.00754.x","type":"journal-article","created":{"date-parts":[[2010,5,13]],"date-time":"2010-05-13T05:01:07Z","timestamp":1273726867000},"page":"389-394","source":"Crossref","is-referenced-by-count":9,"title":["Cervical cytology\/histology discrepancy: a 4\u2010year review of patient outcome"],"prefix":"10.1111","volume":"21","author":[{"given":"E. L.","family":"Moss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Moran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Douce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Parkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. W.","family":"Todd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. W. 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