{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:04:27Z","timestamp":1769598267685,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T00:00:00Z","timestamp":1337644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>T.J. Palmer, S.M. Nicoll, M.E. McKean, A.J. Park, D. Bishop, L. Baker and J.E.A. Imrie \u2028<jats:bold>Prospective parallel randomized trial of the MultiCyte\u2122 ThinPrep<jats:sup>\u00ae<\/jats:sup> imaging system: the Scottish experience<\/jats:bold><\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> Computer\u2010assisted screening of cervical liquid\u2010based cytology (LBC) preparations using the ThinPrep\u00ae Imaging System (TIS) has shown improved qualitative and quantitative gains. The use of Multicyte\u2122 has not been described in a well\u2010established national screening programme with a low incidence of high\u2010grade dyskaryosis.<\/jats:p><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> To assess the impact of computer\u2010assisted screening within the Scottish Cervical Screening Programme (SCSP).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Two groups of three laboratories, each sharing a ThinPrep\u00ae Imager, screened 79\u2003366 slides randomized to test and 90\u2003551 to control arms by laboratory accession. Screeners were not blinded. Standard laboratory reporting profiles of the SCSP, sensitivity, specificity and false\u2010negative rates of all grades of LBC abnormalities with respect to final cytology reports, predictive value for cervical intraepithelial neoplasia grade 2 or worse (CIN2+) on histology; and screening rates were compared for both arms.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Inadequate and negative reporting rates were significantly lower and low\u2010grade reporting rates significantly higher in the imager arm. Imager\u2010assisted screening showed significantly better specificity than manual screening with respect to the final cytology result. There was no evidence of a significant difference in the detection of CIN2\u2003+\u2003 or CIN3\u2003+\u2003. Positive, abnormal and total predictive values (high\u2010grade, low\u2010grade and all abnormal cytology found to be CIN2\u2003+\u2003, respectively) were similar in both arms. Productivity was significantly higher in the imager arm.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Computer\u2010assisted screening in a well established screening programme showed significantly improved productivity without loss of quality. These findings should inform future policy for cervical screening programmes.<\/jats:p>","DOI":"10.1111\/j.1365-2303.2012.00982.x","type":"journal-article","created":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T02:53:00Z","timestamp":1337741580000},"page":"235-245","source":"Crossref","is-referenced-by-count":21,"title":["Prospective parallel randomized trial of the MultiCyte\u2122 ThinPrep<sup>\u00ae<\/sup> imaging system: the Scottish experience"],"prefix":"10.1111","volume":"24","author":[{"given":"T. J.","family":"Palmer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"Nicoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"McKean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E. A.","family":"Imrie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,22]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"ISDScotland.Cervical Cancer Incidence 1975\u20132009.http:\/\/www.isdscotland.org\/Health\u2010Topics\/Cancer\/Publications\/2011\u201008\u201030\/cervical_cancer_screening_change_in_incidence.xls(accessed 18th October 2010)."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605556"},{"key":"e_1_2_6_4_2","first-page":"825","article-title":"Age and automation interact to influence performance of a simulated luggage screening task","volume":"77","author":"Wiegmann D","year":"2006","journal-title":"Aviat Space Environ Med"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20779"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000325959"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.07.025"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20627"},{"key":"e_1_2_6_9_2","unstructured":"ThinPrep\u00ae Imager Feasibility Group.Cervical Cytology Thinprep Imager\u00ae (TIS) Feasibility Study: Report from the Feasibility Sub Group to Cervical Cytology Review Group. 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