{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:49:45Z","timestamp":1760298585657},"reference-count":8,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T00:00:00Z","timestamp":1346112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>J. Bowring, R. Albrow, A. Fisher, G. Downey, J. Cullimore, J. Patnick, P.G. Walker and H.C. Kitchener \u2028<jats:bold>A prospective study of human papillomavirus (HPV) testing to resolve uncertainty in colposcopy<\/jats:bold><\/jats:p><jats:p><jats:bold>Objective:\u2002<\/jats:bold> UK colposcopy services are seeing increased workloads, a large proportion of which are follow\u2010up appointments. The English Cervical Screening Programme HPV Special Interest Group identified five subcategories of colposcopy clinic patients who often require prolonged follow\u2010up regimes for low\u2010grade abnormalities. Human papillomavirus (HPV) testing has a high negative predictive value, meaning that HPV\u2010negative women are at very low risk of underlying disease. Our objectives were to quantify the number of HPV\u2010negative women in each study subcategory and to evaluate the number who could potentially be discharged from colposcopy on the basis of their results.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Four colposcopy clinics prospectively identified women according to five categories over 12\u2003months. All women underwent cytological testing and high\u2010risk HPV (hrHPV) testing using the Hybrid Capture 2 test. Management outcomes and decisions based on a knowledge of the HPV status were recorded.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Data available on 755 women showed that 422\/755 (55.9%) and 260\/755 (34.4%) had persistent cervical intraepithelial neoplasia grade 1 (CIN1) (Category 1) or a minor abnormality following treatment (Category 2), respectively. In Categories 1 and 2, 51.7% and 60.2%, respectively, were hrHPV negative. The rates with biopsies of CIN2 or worse (CIN2+) across the two categories were 3\/355 (0.8%) and 21\/291 (7.0%) for hrHPV\u2010negative and hrHPV\u2010positive women, respectively.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The incorporation of hrHPV testing within organized cervical screening programmes has been widely accepted. hrHPV testing for the clinical scenarios outlined in this study detects women who are hrHPV negative and therefore at low risk of underlying disease, potentially reducing anxiety and inconvenience for women and costs to colposcopy services.<\/jats:p>","DOI":"10.1111\/j.1365-2303.2012.01003.x","type":"journal-article","created":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T07:19:15Z","timestamp":1346138355000},"page":"309-313","source":"Crossref","is-referenced-by-count":6,"title":["A prospective study of human papillomavirus (HPV) testing to resolve uncertainty in colposcopy"],"prefix":"10.1111","volume":"24","author":[{"given":"J.","family":"Bowring","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Albrow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Downey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Cullimore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Patnick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. G.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. C.","family":"Kitchener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq356"},{"key":"e_1_2_6_3_2","first-page":"123","article-title":"Psychological aspects of colposcopy","volume":"10","author":"Freeman\u2010Wang T","year":"2005","journal-title":"CME J Gynecol Oncol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006013.pub2"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.05.117"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00896-09"},{"key":"e_1_2_6_7_2","unstructured":"Department of Health Improving Outcomes: A Strategy for Cancer. London:Department of Health;2011. Available at:http:\/\/www.dh.gov.uk\/prod_consum_dh\/groups\/dh_digitalassets\/documents\/digitalasset\/dh_123394.pdf(Accessed 1 July 2012)."},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.02970.x"},{"key":"e_1_2_6_9_2","unstructured":"The NHS Information Centre Cervical Screening Programme \u2013 England 2010\u20132011. Leeds:The Health and Social Care Information Centre;2011. Available at:http:\/\/www.ic.nhs.uk\/webfiles\/publications\/008_Screening\/cervscreen1011\/Cervical_Bulletin_2010_11_v1_1.pdf(Accessed 1 April 2012)."}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2303.2012.01003.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2303.2012.01003.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T21:21:24Z","timestamp":1696281684000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2303.2012.01003.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,28]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/j.1365-2303.2012.01003.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2303.2012.01003.x","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,28]]}}}