{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T06:41:48Z","timestamp":1792219308113,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,3,20]],"date-time":"2008-03-20T00:00:00Z","timestamp":1205971200000},"content-version":"vor","delay-in-days":9606,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[1981,12]]},"abstract":"<jats:p><jats:bold>Abstract. <\/jats:bold> In forty\u2010two patients with alcoholic liver cirrhosis and without recent alcohol ingestion the pituitary\u2010testicular function was studied in an effort to relate the endocrine abnormalities with the degree of liver cell dysfunction, evaluated on a quantitative basis. Compared with values in twenty\u2010one healthy controls, we found significantly elevated serum oes\u2010trone, oestradiol, follicle\u2010stimulating hormone, luteinizing hormone and prolactin (<jats:italic>P<\/jats:italic> &lt;0middot;01). Serum dehydro\u2010epiandrosterone and dehydroepiandroster\u2010one sulphate were significantly reduced in the cir\u2010rhotics (<jats:italic>P<\/jats:italic> &lt; 0.01), whereas serum testosterone was not significantly different from that in the controls. Raised levels of sex\u2010hormone binding globulin were found in 71% (22\/31) of the patients (median 8 times 10<jats:sup>\u20108<\/jats:sup> mol\/1, range 3\u201317 times 10<jats:sup>\u20108<\/jats:sup> mol\/1). The incidence of gynaeco\u2010mastia (38%), cutaneous spiders (67%), testicular atrophy (24%) and reduced axillary hair (71%) was without significant relation to raised levels of sex\u2010hormone binding globulin or progressively reduced liver function. In the presence of clinical or hormonal hypo\u2010gonadism we found evidence of a state of primary hypogonadism together with an inadequate secretion of gonadotropins. The state of hyperoestro\u2010genaemia and the concentration of gonadotropins were significantly correlated to the hepatic synthesis of coagulation factors.<\/jats:p>","DOI":"10.1111\/j.1365-2362.1981.tb02016.x","type":"journal-article","created":{"date-parts":[[2008,3,20]],"date-time":"2008-03-20T13:44:30Z","timestamp":1206020670000},"page":"473-479","source":"Crossref","is-referenced-by-count":42,"title":["Pituitary\u2010testicular function in patients with alcoholic cirrhosis of the liver"],"prefix":"10.1111","volume":"11","author":[{"given":"M.","family":"BAHNSEN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"GLUUD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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