{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:34:21Z","timestamp":1760204061953},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,4,7]],"date-time":"2005-04-07T00:00:00Z","timestamp":1112832000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Indomethacin\u2010induced enteritis is a model of inflammatory bowel disease.<\/jats:p><jats:p><jats:bold>Materials and methods\u2002<\/jats:bold> To further characterize this model, rats received two injections of indomethacin (7\u00b75\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>) 24\u00a0h apart and histological damage of intestinal mucosa, oxidative stress, alterations of intestinal motility and mesenteric vascular bed (MVB) reactivity were investigated after 5\u00a0days.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The results show that indomethacin caused several histological and functional changes at the ileal level. In particular, response to carbachol as well as the nonadrenergic\u2010noncholinergic inhibitory response to electrical field stimulation (EFS) was lower in the treated than control rats. Moreover, nitric oxide (NO)\u2010component of the inhibitory response was higher in the treated than control rats. Mesenteric vessels preparations from the treated rats showed increased noradrenaline (NA)\u2010induced perfusion pressure, whereas relaxant responses to acetylcholine, although not significantly reduced in the treated rats, had a higher nitrergic component. This finding suggests that vascular dysfunction may contribute to chronic inflammation. Indomethacin injection also determined acute and severe oxidative stress in ileum mucosa.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> In conclusion, our study contributes to further characterize the rat model of indomethacin\u2010induced enteritis and suggests that it is suitable for drug screening in rats, as this model can be obtained in a very short period and is simple and reproducible.<\/jats:p>","DOI":"10.1111\/j.1365-2362.2005.01489.x","type":"journal-article","created":{"date-parts":[[2005,4,7]],"date-time":"2005-04-07T14:32:09Z","timestamp":1112884329000},"page":"271-278","source":"Crossref","is-referenced-by-count":10,"title":["Indomethacin\u2010induced ileitis is associated with tensiometric, vascular and oxidative changes in the experimental rat model"],"prefix":"10.1111","volume":"35","author":[{"given":"A. 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