{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T20:16:17Z","timestamp":1773260177589,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,2,27]],"date-time":"2006-02-27T00:00:00Z","timestamp":1140998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Cholesterol cholelithiasis (gallstone disease) is a common disease in the Western world. The aim of the present study was to analyze the hepatic expression of a number of nuclear receptors involved in bile acid metabolism in human cholesterol gallstone disease.<\/jats:p><jats:p><jats:bold>Materials and methods\u2002<\/jats:bold> Surgical liver biopsies were obtained from 11\u00a0patients with untreated cholesterol cholelithiasis and nine\u00a0gallstone\u2010free subjects; mRNA levels of cholesterol 7\u03b1\u2010hydroxylase (CYP7A1) and related nuclear receptors and coactivators were assayed by quantitative real\u2010time RT\u2010PCR.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> No differences between the two groups were detected in mRNA levels of CYP7A1 and related nuclear receptors, with the exception of peroxysome proliferator\u2010activated receptor\u2010\u03b3 coactivator 1 (PGC\u20101), which was significantly (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b701) less expressed in gallstone subjects. Expression of PGC\u20101 was linearly correlated with farnesoid X receptor (FXR) in gallstone patients (<jats:italic>r\u00a0=<\/jats:italic>\u00a00\u00b787 on a log scale, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701), but not in control subjects; in gallstone patients PGC\u20101 expression was also correlated with hepatocyte nuclear factor 4 (HNF\u20104) (<jats:italic>r\u00a0=<\/jats:italic>\u00a00\u00b778, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> These findings suggest that PGC\u20101 can play a role in the prevention of cholesterol gallstone disease in humans; this might take place via interaction with the bile acid receptor FXR, whose protective role in cholelithiasis has been suggested by recent evidence in animal models and other coactivators. The present data might help to understand the pathophysiology and possibly focus on new therapeutical targets in cholesterol gallstone disease.<\/jats:p>","DOI":"10.1111\/j.1365-2362.2006.01607.x","type":"journal-article","created":{"date-parts":[[2006,2,27]],"date-time":"2006-02-27T11:13:45Z","timestamp":1141038825000},"page":"170-175","source":"Crossref","is-referenced-by-count":30,"title":["Decreased hepatic expression of PPAR\u2010\u03b3 coactivator\u20101 in cholesterol cholelithiasis"],"prefix":"10.1111","volume":"36","author":[{"given":"M.","family":"Bertolotti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Gabbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Anzivino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Mitro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Godio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"De Fabiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Crestani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Del Puppo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ricchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Carulli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Loria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Carulli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.77.906.221"},{"key":"e_1_2_6_3_2","first-page":"8","article-title":"Gallstones \u2013 approach to medical management","volume":"5","author":"Konikoff FM","year":"2003","journal-title":"Med General Med"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105794"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0016-5085(82)80401-0","article-title":"Effects of acute bile acid administration on biliary lipid secretion in healthy volunteers","volume":"82","author":"Sama C","year":"1982","journal-title":"Gastroenterology"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111459"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S0022-2275(20)38111-6","article-title":"Hepatic cholesterol metabolism in obesity: activity of microsomal 3\u2010hydroxy\u20103\u2010methylglutaryl co\u2010enzyme A reductase","volume":"23","author":"Angelin B","year":"1982","journal-title":"J Lipid Res"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0022-2275(20)38795-2","article-title":"Biliary lipid secretion in patients with hypercholesterolemia and combined hyperlipidemia. 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