{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:54:19Z","timestamp":1787014459982,"version":"build-2736575974"},"reference-count":82,"publisher":"Wiley","issue":"s2","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background\u2002<\/jats:bold>\n                    The study of a distinct group of renal phosphate wasting disorders with bone disease which comprise X\u2010linked hypophosphatemic rickets (XLH), autosomal dominant hypophosphatemic rickets (ADHR) and tumour\u2010induced osteomalacia (TIO) gave rise to the identification of different hormone\u2010like peptides, also known as phosphatonins. These factors are responsible for the major disease features that characterize XLH, ADHR and TIO. Recent reports on one of these phosphatonins, fibroblast growth factor\u201023 (FGF\u201023), point to a general role of this factor in mineral ion metabolism.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objectives\u2002<\/jats:bold>\n                    The main focus regards recent evidence implicating FGF\u201023 in normal and disordered mineral homeostasis with special emphasis on chronic kidney disease. The interactions of FGF\u201023 with phosphate, parathyroid hormone and vitamin\u00a0D are discussed in detail.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Summary\u2002<\/jats:bold>\n                    The FGF\u201023 has been shown to increase urinary phosphate excretion, inhibit bone mineralization and suppress 1,25\u2010dihydroxy vitamin\u00a0D\n                    <jats:sub>3<\/jats:sub>\n                    [1,25(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    ], the main characteristics that XLH, ADHR and TIO have in common. Apart from its role in these phosphate wasting disorders serum FGF\u201023 is elevated in hypoparathyroidism and humoral hypercalcaemia of malignancy and responds to altered dietary phosphate and calcium supply in healthy subjects. The FGF\u201023 is also variably elevated in chronic kidney disease and associated secondary hyperparathyroidism where it correlates positively with serum phosphate and parathyroid hormone and negatively with 1,25(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    . Such relationships, along with data from experimental studies, raise the question of whether FGF\u201023 contributes to the pathophysiology of chronic kidney disease.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2362.2006.01659.x","type":"journal-article","created":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T03:44:24Z","timestamp":1152675864000},"page":"34-42","source":"Crossref","is-referenced-by-count":16,"title":["Emerging role of a phosphatonin in mineral homeostasis and its 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