{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:26:11Z","timestamp":1792707971283,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,6,6]],"date-time":"2006-06-06T00:00:00Z","timestamp":1149552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Anabolic androgenic steroids are used by some bodybuilders to enhance performance. While the cardiovascular implications of supraphysiological androgen levels requires further clarification, use is associated with sudden death, left ventricular hypertrophy, thrombo\u2010embolism and cerebro\u2010vascular events.<\/jats:p><jats:p><jats:bold>Materials and methods\u2002<\/jats:bold> To further understand the effect of androgenic anabolic steroid abuse on vascular function, this study assessed vascular stiffness (pulse\u2010wave analysis) and cardiovascular risk factors in 28 male, bodybuilding subjects, of whom ten were actively receiving anabolic agents (group\u00a0A; 26\u00b74\u00a0\u00b1\u00a07\u00b72\u00a0years) and eight had undergone a 3\u2010month \u2018wash\u2010out\u2019 period (group\u00a0B; 32\u00b71\u00a0\u00b1\u00a07\u00b71\u00a0years). The remaining ten bodybuilding subjects (group\u00a0C; 24\u00b74\u00a0\u00b1\u00a04\u00b74\u00a0years) denied any past use of anabolic steroids or other performance enhancing drugs. Comparisons were made with ten sedentary male controls (group\u00a0D, 29\u00b73\u00a0\u00b1\u00a04\u00b77\u00a0years).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Endothelial independent dilatation in response to glycerol trinitrate was significantly impaired in the group currently using anabolic steroids (group\u00a0A) compared with the other three groups [A\u00a0(5\u00b763\u00a0\u00b1\u00a03\u00b724%) versus; B\u00a0(11\u00b710\u00a0\u00b1\u00a04\u00b791%), C\u00a0(17\u00b788\u00a0\u00b1\u00a09\u00b72%) and D\u00a0(14\u00b746\u00a0\u00b1\u00a03\u00b79%), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70005, respectively], whereas no significant differences in endothelial\u2010dependant dilatation were detected between the groups [A\u00a0(5\u00b70\u00a0\u00b1\u00a03\u00b70%), B\u00a0(7\u00b74\u00a0\u00b1\u00a03\u00b74%), C\u00a0(9\u00b76\u00a0\u00b1\u00a04\u00b75%) and D\u00a0(8\u00b72\u00a0\u00b1\u00a03\u00b73%), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7059, respectively].<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Previous studies described a decline in vascular reactivity occurring in bodybuilding subjects which is independent of anabolic steroid use and may result from smooth muscle hypertrophy with increased vascular stiffness. This study revealed impaired vascular reactivity associated with anabolic agents and that improvement in vascular function may occur following their discontinuation.<\/jats:p>","DOI":"10.1111\/j.1365-2362.2006.01667.x","type":"journal-article","created":{"date-parts":[[2006,6,7]],"date-time":"2006-06-07T09:44:01Z","timestamp":1149673441000},"page":"483-488","source":"Crossref","is-referenced-by-count":55,"title":["Impaired vasoreactivity in bodybuilders using androgenic anabolic steroids"],"prefix":"10.1111","volume":"36","author":[{"given":"H. A.","family":"Lane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Grace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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