{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T12:13:55Z","timestamp":1697285635417},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Post\u2010prandial lipid abnormalities might contribute to the excess of cardiovascular risk typical of type\u00a02 diabetic patients. The study evaluated the effects of atorvastatin (20\u00a0mg\u00a0d<jats:sup>\u22121<\/jats:sup>) vs. fenofibrate (200\u00a0mg\u00a0d<jats:sup>\u22121<\/jats:sup>) on post\u2010prandial lipids in type\u00a02 diabetic patients with mixed hyperlipidaemia.<\/jats:p><jats:p><jats:bold>Materials and methods\u2002<\/jats:bold> Eight type\u00a02 diabetic patients, male\/female (M\/F) 6\/2, age 58\u00a0\u00b1 5\u00a0years, body mass index (BMI) 28\u00a0\u00b1\u00a03\u00a0kg\u00a0m<jats:sup>\u22122<\/jats:sup> with cholesterol of low\u2010density lipoprotein (LDL) between 100\u2013160\u00a0mg\u00a0dL<jats:sup>\u22121<\/jats:sup> and triglycerides between 150\u2013400\u00a0mg\u00a0dL<jats:sup>\u22121<\/jats:sup>, participated in a randomized, cross\u2010over study (3\u00a0months on atorvastatin and 3\u00a0months on fenofibrate). At baseline and at the end of the two treatments, the patients were given a standard fat meal; blood samples were taken before the meal and every 2\u00a0h after for the assay of cholesterol, triglycerides, apoB\u201048 and apoB\u2010100 (determined by sodium dodecyl sulphate\u2010polyacrylamide gel electrophoresis) in plasma lipoproteins and very low\u2010density lipoprotein (VLDL) subfractions (large and small VLDL), separated by density gradient ultracentrifugation.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Data on fasting lipids confirmed that atorvastatin was more effective on the reduction of LDL\u2010cholesterol, whereas fenofibrate was a better triglyceride\u2010lowering agent. Concerning the post\u2010prandial phase, the incremental areas under the curve (IAUC) for chylomicrons and large VLDL were reduced after both treatments, reaching statistical significance for cholesterol, triglyceride and apoB\u2010100 content of chylomicrons only after fenofibrate administration [IAUC, (5\u00b72\u00a0\u00b1\u00a04\u00b76\u00a0vs.\u00a010\u00b77\u00a0\u00b1\u00a09\u00b73)\u00a0mg\u00a0dL<jats:sup>\u22121<\/jats:sup>\u00a0h<jats:sup>\u22121<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b703; (131\u00b73\u00a0\u00b1\u00a095\u00b71\u00a0vs.\u00a0259\u00b71\u00a0\u00b1\u00a0201\u00b75)\u00a0mg\u00a0dL<jats:sup>\u22121<\/jats:sup>\u00a0h<jats:sup>\u22121<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702; (0\u00b746\u00a0\u00b1\u00a01\u00a0vs.\u00a03\u00a0\u00b1\u00a03\u00b77)\u00a0mg\u00a0dL<jats:sup>\u22121<\/jats:sup>\u00a0h<jats:sup>\u22121<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7025, all respectively].<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> During the post\u2010prandial state fenofibrate appeared to be more effective than atorvastatin in reducing the chylomicron response.<\/jats:p>","DOI":"10.1111\/j.1365-2362.2006.01677.x","type":"journal-article","created":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T20:08:16Z","timestamp":1153253296000},"page":"560-565","source":"Crossref","is-referenced-by-count":5,"title":["Atorvastatin or fenofibrate on post\u2010prandial lipaemia in type\u00a02 diabetic patients with hyperlipidaemia"],"prefix":"10.1111","volume":"36","author":[{"given":"C.","family":"Iovine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lilli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gentile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Patti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Di Marino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Cipriano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Riccardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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