{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T05:17:32Z","timestamp":1719724652860},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T00:00:00Z","timestamp":1158019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Intestinal mucosal damage causes impaired digestive capacity and increased mucosal permeability. Quantification of damage can be used to improve treatment options. Currently, the Lactose Digestion Index (LDI) and the Sugar Absorption Test (SAT) are used for evaluation. The investigation studied whether both tests could be combined to provide a useful multifunctional test and whether measurements in blood (LDI) could be replaced by measurements in urine.<\/jats:p><jats:p><jats:bold>Materials and methods\u2002<\/jats:bold> The LDI (25\u00a0g <jats:sup>13<\/jats:sup>C\u2010lactose, 0\u00b75\u00a0g <jats:sup>2<\/jats:sup>H\u2010glucose), the SAT (5\u00a0g lactulose, 1\u00a0g L\u2010rhamnose) and the LDI\/SAT combination test were performed in seven lactose\u2010digesting and eight lactose\u2010maldigesting adults. Plasma glucose <jats:sup>13<\/jats:sup>C\u2010enrichment was determined by gas\u2010chromatography\/combustion\/isotope ratio mass\u2010spectrometry (GC\/C\/IRMS), <jats:sup>2<\/jats:sup>H enrichment determined by gas\u2010chromatography\/mass\u2010spectrometry (GC\/MS) and urinary sugars by gas\u2010chromatography (GC).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The results of the separate LDI test were not different from those of the LDI\/SAT in the lactose\u2010digester group (0\u00b782\u00a0\u00b1\u00a00\u00b706\u00a0vs.\u00a00\u00b781\u00a0\u00b1\u00a00\u00b709), nor in the lactose\u2010maldigester group (0\u00b736\u00a0\u00b1\u00a00\u00b712\u00a0vs.\u00a00\u00b735\u00a0\u00b1\u00a00\u00b706). A significant correlation was found between the 10\u2010h urinary\u2010lactose\/lactulose ratio and the LDI (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00\u00b771, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701). There were no differences in the lactulose\/L\u2010rhamnose ratio between lactose\u2010digesters and lactose\u2010maldigesters using both the SAT and LDI\/SAT tests.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The LDI\/SAT test is a reliable method of measuring digestion and permeability simultaneously. The 10\u2010h period urinary lactose\/lactulose excretion ratio following lactose consumption reflects lactose digestive capacity.<\/jats:p>","DOI":"10.1111\/j.1365-2362.2006.01717.x","type":"journal-article","created":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T15:06:28Z","timestamp":1158073588000},"page":"730-736","source":"Crossref","is-referenced-by-count":4,"title":["Combined LDI\/SAT test to evaluate intestinal lactose digestion and mucosa permeability"],"prefix":"10.1111","volume":"36","author":[{"given":"H. 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