{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:13:10Z","timestamp":1773673990769,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,8,18]],"date-time":"2008-08-18T00:00:00Z","timestamp":1219017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Our team previously demonstrated arterial stiffening and cardiac hypertrophy in type\u00a02 diabetic rats at 8 but not 4\u00a0weeks after being administered streptozotocin (STZ) and nicotinamide (NA). The present study focused on investigating the effects of type\u00a02 diabetes on cardiac autonomic nerve function in the STZ\u2010 and NA\u2010treated animals, using modern spectral estimation technique.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> An autoregressive process was performed to each detrended signal of heart rate and systolic blood pressure measured in the 4\u2010 and 8\u2010week STZ\u2010NA rats with anaesthesia. The power of low\u2010frequency and high\u2010frequency oscillations was automatically quantified with each spectral peak by computing the residuals. The closed\u2010loop baroreflex gain was estimated using the square root of the ratio between heart rate and systolic blood pressure powers in the low\u2010frequency band.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Compared with the age\u2010matched controls, both the 4\u2010 and 8\u2010week STZ\u2010NA diabetic rats had significantly decreased low\u2010frequency oscillations of heart rate but not systolic blood pressure variability, showing a decline in baroreflex gain (0\u00b7451\u00a0\u00b1\u00a00\u00b7060 and 0\u00b7484\u00a0\u00b1\u00a00\u00b7056 vs. 1\u00b7196\u00a0\u00b1\u00a00\u00b7064\u00a0ms\u00a0mmHg<jats:sup>\u22121<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). On the other hand, the low\u00a0frequency\u2013high\u00a0frequency power ratio of the heart period was also diminished in the two diabetic groups, indicating a shift in sympatho\u2010vagal balance of the heart control (0\u00b7472\u00a0\u00b1\u00a00\u00b7109 and 0\u00b7504\u00a0\u00b1\u00a00\u00b7090 vs. 1\u00b7857\u00a0\u00b1\u00a00\u00b7336, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> The cardiac autonomic dysfunction in the absence of any significant changes in vascular dynamics, 4 but not 8\u00a0weeks after induction of type\u00a02 diabetes, suggests that the diabetic autonomic neuropathy may precede arterial stiffening and cardiac hypertrophy in the STZ\u2010 and NA\u2010treated rats.<\/jats:p>","DOI":"10.1111\/j.1365-2362.2008.01992.x","type":"journal-article","created":{"date-parts":[[2008,8,18]],"date-time":"2008-08-18T19:03:52Z","timestamp":1219086232000},"page":"607-614","source":"Crossref","is-referenced-by-count":10,"title":["Autonomic neuropathy precedes cardiovascular dysfunction in rats with 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