{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:47:54Z","timestamp":1787064474870,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1685,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1111\/j.1365-2362.2010.02461.x","type":"journal-article","created":{"date-parts":[[2011,1,20]],"date-time":"2011-01-20T04:23:19Z","timestamp":1295497399000},"page":"734-742","source":"Crossref","is-referenced-by-count":45,"title":["Oxidative stress and autonomic nervous system functions in restless legs syndrome"],"prefix":"10.1111","volume":"41","author":[{"given":"Mehmet Ali","family":"Cikrikcioglu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Hursitoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafize","family":"Erkal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcin Erdem","family":"K\u0131nas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Sztajzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Cakirca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysun Guneri","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aybala","family":"Erek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulistan","family":"Halac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tufan","family":"Tukek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,20]]},"reference":[{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB1|cit1","unstructured":"Tarsy D Sheon RP Restless legs syndrome"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/00004691-200103000-00004","article-title":"Restless legs syndrome: a review of clinical and pathophysiologic features","volume":"18","author":"Allen","year":"2001","journal-title":"J Clin Neurophysiol"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB3|cit3","first-page":"22","article-title":"Oxidative stress in ocular disease","volume":"112","author":"Ohira","year":"2008","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.clinbiochem.2005.08.008","article-title":"A new automated colorimetric method for measuring total oxidant status","volume":"38","author":"Erel","year":"2005","journal-title":"Clin Biochem"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.clinbiochem.2003.11.015","article-title":"A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation","volume":"37","author":"Erel","year":"2004","journal-title":"Clin Biochem"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1590\/S1807-59322010000200009","article-title":"Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients","volume":"65","author":"Erdem","year":"2010","journal-title":"Clinics (Sao Paulo)"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1096\/fj.04-2106fje","article-title":"Acetylcholinesterase\/paraoxonase interactions increase the risk of insecticide-induced Parkinson\u2019s disease","volume":"19","author":"Benmoyal-Segal","year":"2005","journal-title":"FASEB J"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB8|cit8","first-page":"1126","article-title":"The human serum paraoxonase\/arylesterase polymorphism","volume":"35","author":"Eckerson","year":"1983","journal-title":"Am J Hum Genet"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB9|cit9","first-page":"214","article-title":"The human serum paraoxonase polymorphism: identification of phenotypes by their response to salts","volume":"35","author":"Eckerson","year":"1983","journal-title":"Am J Hum Genet"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB10|cit10","first-page":"101","article-title":"Acetylcholinesterase\/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study","volume":"13","author":"Sklan","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1196\/annals.1427.023","article-title":"Oxidative stress in Parkinson\u2019s disease: a mechanism of pathogenic and therapeutic significance","volume":"1147","author":"Zhou","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1358\/mf.2008.30.10.1316822","article-title":"Chronic emotional stress exposure increases infarct size in rats: the role of oxidative and nitrosative damage in response to sympathetic hyperactivity","volume":"30","author":"Mercanoglu","year":"2008","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0076-6879(99)00113-5","article-title":"Ferrous ion oxidation in presence of xylenol orange for detection of lipid hydroperoxides in plasma","volume":"300","author":"Nourooz Zadeh","year":"1999","journal-title":"Methods Enzymol"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB14|cit14","unstructured":"BioAssay Systems http:\/\/www.genoprice.com\/DACE1.pdf"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.CIR.93.5.1043","article-title":"Heart rate variability: standards of measurement, physiological interpretation and clinical use","volume":"93","author":"Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology","year":"1996","journal-title":"Circulation"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1194\/jlr.M400144-JLR200","article-title":"Preferential inhibition of paraoxonase activity of human paraoxonase 1 by negatively charged lipids","volume":"45","author":"Nguyen","year":"2004","journal-title":"J Lipid Res"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1080\/5760310001621351-1","article-title":"Oxidative inactivation of paraoxonase1, an antioxidant protein and its effect on antioxidant action","volume":"37","author":"Nguyen","year":"2003","journal-title":"Free Radic Res"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0891-5849(98)00272-X","article-title":"Human serum paraoxonase (PON1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants","volume":"26","author":"Aviram","year":"1999","journal-title":"Free Radic Biol Med"},{"issue":"Pt 9","key":"10.1111\/j.1365-2362.2010.02461.x-BIB19|cit19","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1093\/brain\/awp125","article-title":"Altered dopaminergic profile in the putamen and substantia nigra in restless legs syndrome","volume":"132","author":"Connor","year":"2009","journal-title":"Brain"},{"issue":"1 Suppl 1","key":"10.1111\/j.1365-2362.2010.02461.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/j.amjmed.2006.11.003","article-title":"Controversies and challenges in defining the etiology and pathophysiology of restless legs syndrome","volume":"120","author":"Allen","year":"2007","journal-title":"Am J Med"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF00712800","article-title":"A noncholinergic action of acetylcholinesterase (AChE) in the brain: from neuronal secretion to the generation of movement","volume":"11","author":"Greenfield","year":"1991","journal-title":"Cell Mol Neurobiol"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB22|cit22","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0891-5849(94)00115-Z","article-title":"A possible interaction between acetylcholinesterase and dopamine molecules during autoxidation of the amine","volume":"18","author":"Klegeris","year":"1995","journal-title":"Free Radic Biol Med"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/(SICI)1097-4547(19970715)49:2<207::AID-JNR9>3.0.CO;2-D","article-title":"Non-cholinergic, trophic action of recombinant acetylcholinesterase on mid-brain dopaminergic neurons","volume":"49","author":"Holmes","year":"1997","journal-title":"J Neurosci Res"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/bj2600625","article-title":"Comparison of butyrylcholinesterase and acetylcholinesterase","volume":"260","author":"Chatonnet","year":"1989","journal-title":"Biochem J"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1755-5949.2010.00142.x","article-title":"Acetylcholine-Dopamine interactions in the pathophysiology and treatment of CNS disorders","volume":"16","author":"Lester","year":"2010","journal-title":"CNS Neurosci Ther"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"34887","DOI":"10.1074\/jbc.M805682200","article-title":"Formation of dopamine adducts derived from brain polyunsaturated fatty acids: mechanism for Parkinson disease","volume":"283","author":"Liu","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.atherosclerosis.2006.04.007","article-title":"Assessment of paraoxonase and arylesterase activities in patients with iron deficiency anemia","volume":"191","author":"Aslan","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1515\/CCLM.2006.156","article-title":"Longitudinal changes in serum paraoxonase-1 activity throughout normal pregnancy","volume":"44","author":"Ferr\u00e9","year":"2006","journal-title":"Clin Chem Lab Med"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1542-4758.2008.00311.x","article-title":"Paraoxonase-1 (PON1) activity as a risk factor for atherosclerosis in chronic renal failure patients","volume":"12","author":"Saeed","year":"2008","journal-title":"Hemodial Int"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0022-3999(04)00020-0","article-title":"Restless legs syndrome and periodic limb movement disorder in the elderly","volume":"56","author":"Hornyak","year":"2004","journal-title":"J Psychosom Res"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.exger.2003.08.001","article-title":"Study of factors influencing the decreased HDL associated PON1 activity with aging","volume":"39","author":"Seres","year":"2004","journal-title":"Exp Gerontol"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB32|cit32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/(SICI)1096-8652(199901)60:1<19::AID-AJH4>3.0.CO;2-1","article-title":"Use of the platelet histogram maximum in evaluating thrombocytopenia","volume":"60","author":"Niethammer","year":"1999","journal-title":"Am J Hematol"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB33|cit33","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1111\/j.1742-1241.2009.02070.x","article-title":"The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases","volume":"63","author":"Vizioli","year":"2009","journal-title":"Int J Clin Pract"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1023\/B:THRO.0000037666.01018.8c","article-title":"Mean platelet volume and exercise stress test","volume":"17","author":"Yilmaz","year":"2004","journal-title":"J Thromb Thrombolysis"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB35|cit35","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1212\/01.wnl.0000253186.23949.fd","article-title":"Protective effects of beta-blockers in cerebrovascular disease","volume":"68","author":"Laowattana","year":"2007","journal-title":"Neurology"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"160","DOI":"10.2165\/00007256-199520030-00004","article-title":"Exercise and brain neurotransmission","volume":"20","author":"Meeusen","year":"1995","journal-title":"Sports Med"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB37|cit37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/17461390100071103","article-title":"Exercise and Neurotransmission: a Window to the Future?","volume":"1","author":"Meeusen","year":"2001","journal-title":"Eur J Sport Sci"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB38|cit38","doi-asserted-by":"crossref","first-page":"5291","DOI":"10.1523\/JNEUROSCI.1069-07.2007","article-title":"Effects of treadmill exercise on dopaminergic transmission in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury","volume":"27","author":"Petzinger","year":"2007","journal-title":"J Neurosci"},{"issue":"6 Pt 1","key":"10.1111\/j.1365-2362.2010.02461.x-BIB39|cit39","first-page":"E806","article-title":"Epinephrine augments cortisol secretion from isolated perfused adrenal glands of guinea pigs","volume":"262","author":"Mokuda","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB40|cit40","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.steroids.2005.10.008","article-title":"Differential effects of hydrocortisone on sympathetic and hemodynamic responses to sympathoexcitatory manoeuvres in men","volume":"71","author":"Heindl","year":"2006","journal-title":"Steroids"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB41|cit41","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1038\/sj.npp.1301597","article-title":"Stress-induced dopamine release in humans at risk of psychosis: a [11C]raclopride PET study","volume":"33","author":"Soliman","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB42|cit42","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0006-3223(97)00550-7","article-title":"Hypothalamic-pituitary-adrenal axis effects on plasma homovanillic acid in man","volume":"45","author":"Posener","year":"1999","journal-title":"Biol Psychiatry"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB43|cit43","first-page":"93","article-title":"Glucocorticoids have state-dependent stimulant effects on the mesencephalic dopaminergic transmission","volume":"6","author":"Piazza","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB44|cit44","first-page":"70","article-title":"Low-dose hydrocortisone in the evening modulates symptom severity in restless legs syndrome","volume":"29","author":"Hornyak","year":"2008","journal-title":"Neurology"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB45|cit45","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/PL00007857","article-title":"Endocrine rhythms in patients with restless legs syndrome","volume":"249","author":"Wetter","year":"2002","journal-title":"J Neurol"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB46|cit46","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/ana.10843","article-title":"Circadian rhythm of restless legs syndrome: relationship with biological markers","volume":"55","author":"Michaud","year":"2004","journal-title":"Ann Neurol"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB47|cit47","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.sleep.2004.01.007","article-title":"Circadian effects of dopaminergic treatment in restless legs syndrome","volume":"5","author":"Garcia-Borreguero","year":"2004","journal-title":"Sleep Med"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB48|cit48","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/BF03351014","article-title":"Circadian variation in plasma dopamine levels in man","volume":"7","author":"Sowers","year":"1984","journal-title":"J Endocrinol Invest"},{"issue":"5 Pt 1","key":"10.1111\/j.1365-2362.2010.02461.x-BIB49|cit49","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1523\/JNEUROSCI.14-05-02724.1994","article-title":"Corticosterone circadian secretion differentially facilitates dopamine-mediated psychomotor effect of cocaine and morphine","volume":"14","author":"Marinelli","year":"1994","journal-title":"J Neurosci"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB50|cit50","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/syn.20682","article-title":"Differential corticosteroid receptor regulation of mesoaccumbens dopamine efflux during the peak and nadir of the circadian rhythm: a molecular equilibrium in the midbrain?","volume":"63","author":"Tye","year":"2009","journal-title":"Synapse"},{"key":"10.1111\/j.1365-2362.2010.02461.x-BIB51|cit51","first-page":"57","volume-title":"Principles and Practice of Endocrinology and Metabolism","author":"Van Cauter","year":"2002"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2362.2010.02461.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1365-2362.2010.02461.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T21:06:56Z","timestamp":1625346416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2362.2010.02461.x"}},"subtitle":["OXIDATIVE STRESS IN RLS"],"short-title":[],"issued":{"date-parts":[[2011,1,20]]},"references-count":51,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1365-2362.2010.02461.x","relation":{},"ISSN":["0014-2972"],"issn-type":[{"value":"0014-2972","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1,20]]}}}