{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:19:09Z","timestamp":1790875149510,"version":"4.1.0"},"reference-count":156,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>Eur J Clin Invest 2012; 42 (1): 95\u2013109<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Interleukin\u201010 is a pleiotropic cytokine, whose main function is limitation and ultimately termination of immune responses. This is especially true for environmental interfaces such as the gastrointestinal tract. IL\u201010 acts as a key mediator for maintaining gut homeostasis. IL\u201010 knockout mice are well established as a genetic model for inflammatory bowel disease (IBD), and sequence variants in the IL\u201010 locus contribute to ulcerative colitis (UC).<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> This review covers the significance of IL\u201010 signalling in the intestinal immune response both in health and disease. It explains the biological role of IL\u201010, its deregulation in IBD and its contribution to intestinal inflammation via endoplasmic reticulum stress response.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Many IBD susceptibility genes have been discovered in the past years, linking fundamental biological systems, like innate and adaptive immunity, stress responses, autophagy and mucosal barrier to the pathogenesis of Crohn\u2019s disease (CD) and UC. IL\u201010 has long been known for its substantial role in regulating gut immunity, but its contribution to IBD was somewhat elusive. A recent study identified mutations in either IL\u201010 receptor subunits that are associated with early\u2010onset enterocolitis, a severe phenotype of IBD. Other than genetic variants of IL\u201010 receptors, IL\u201010 and STAT3 genes are also associated with IBD, emphasizing the involvement of the IL\u201010 signalling cascade in the pathogenesis of CD and UC.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> The discovery of inherited deregulations in the IL\u201010 signalling cascade is not only considered the missing link between IL\u201010 and intestinal homeostasis, but also demonstrates how findings made in animal models help explaining human disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2362.2011.02552.x","type":"journal-article","created":{"date-parts":[[2011,6,3]],"date-time":"2011-06-03T12:27:09Z","timestamp":1307104029000},"page":"95-109","source":"Crossref","is-referenced-by-count":96,"title":["Inflamed gut mucosa: downstream of interleukin\u201010"],"prefix":"10.1111","volume":"42","author":[{"given":"Gregor","family":"Paul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineeta","family":"Khare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Gasche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6]]},"reference":[{"key":"e_1_2_18_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06005"},{"key":"e_1_2_18_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804647"},{"key":"e_1_2_18_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/07853890903559724"},{"key":"e_1_2_18_5_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i23.3668"},{"key":"e_1_2_18_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000234909"},{"key":"e_1_2_18_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21375"},{"key":"e_1_2_18_8_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i46.6134"},{"key":"e_1_2_18_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90663-A"},{"key":"e_1_2_18_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20295"},{"key":"e_1_2_18_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.11.5224-5231.1998"},{"key":"e_1_2_18_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.6.2359"},{"key":"e_1_2_18_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907206"},{"key":"e_1_2_18_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)80068-P"},{"key":"e_1_2_18_15_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.6.2081"},{"key":"e_1_2_18_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.02.026"},{"key":"e_1_2_18_17_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.76.060605.122847"},{"key":"e_1_2_18_18_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0110001"},{"key":"e_1_2_18_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4302"},{"key":"e_1_2_18_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.2.741"},{"key":"e_1_2_18_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.7.4312"},{"key":"e_1_2_18_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.9.3295.bloodjournal8693295"},{"key":"e_1_2_18_23_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006672114184"},{"key":"e_1_2_18_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.4.1006"},{"key":"e_1_2_18_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.102111"},{"key":"e_1_2_18_26_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0191"},{"key":"e_1_2_18_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.10.020"},{"key":"e_1_2_18_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.11.038"},{"key":"e_1_2_18_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.09.016"},{"key":"e_1_2_18_30_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.2312"},{"key":"e_1_2_18_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200940294"},{"key":"e_1_2_18_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199909)29:09<2658::AID-IMMU2658>3.0.CO;2-G"},{"key":"e_1_2_18_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364135"},{"key":"e_1_2_18_34_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0405201"},{"key":"e_1_2_18_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2004.09.002"},{"key":"e_1_2_18_36_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.3181"},{"key":"e_1_2_18_37_2","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.4049\/jimmunol.163.5.2530","article-title":"Inhibition of kit expression by IL\u20104 and IL\u201010 in murine mast cells: role of STAT6 and phosphatidylinositol 3\u2032\u2010kinase","volume":"163","author":"Mirmonsef P","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_18_38_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012220"},{"key":"e_1_2_18_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr070222x"},{"key":"e_1_2_18_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.07.021"},{"key":"e_1_2_18_41_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.206466"},{"key":"e_1_2_18_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.05.012"},{"key":"e_1_2_18_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80156-9"},{"key":"e_1_2_18_44_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207577200"},{"key":"e_1_2_18_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.01.001"},{"key":"e_1_2_18_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1488"},{"key":"e_1_2_18_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00499-07"},{"key":"e_1_2_18_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1539"},{"key":"e_1_2_18_49_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900123"},{"key":"e_1_2_18_50_2","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.4049\/jimmunol.152.9.4368","article-title":"B7\/CD28\u2010dependent IL\u20105 production by human resting T cells is inhibited by IL\u201010","volume":"152","author":"Schanden\u00e9 L","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_18_51_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.150.2.353"},{"key":"e_1_2_18_52_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041789"},{"key":"e_1_2_18_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.02.017"},{"key":"e_1_2_18_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1485"},{"key":"e_1_2_18_55_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.2.170"},{"key":"e_1_2_18_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1504"},{"key":"e_1_2_18_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909122107"},{"key":"e_1_2_18_58_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001156"},{"key":"e_1_2_18_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh367"},{"key":"e_1_2_18_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(94)90045-0"},{"key":"e_1_2_18_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1791"},{"key":"e_1_2_18_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni904"},{"key":"e_1_2_18_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2010.84"},{"key":"e_1_2_18_64_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2583"},{"key":"e_1_2_18_65_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.6920"},{"key":"e_1_2_18_66_2","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.4049\/jimmunol.143.4.1118","article-title":"Cloned natural suppressor cell lines express the CD3+CD4\u2212CD8\u2212 surface phenotype and the alpha, beta heterodimer of the T cell antigen receptor","volume":"143","author":"Strober S","year":"1989","journal-title":"J Immunol"},{"key":"e_1_2_18_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2003.08.030"},{"key":"e_1_2_18_68_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.1.134"},{"key":"e_1_2_18_69_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.042692799"},{"key":"e_1_2_18_70_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.5.1890"},{"key":"e_1_2_18_71_2","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.4049\/jimmunol.154.9.4341","article-title":"The role of IL\u201010 in human B cell activation, proliferation, and differentiation","volume":"154","author":"Itoh K","year":"1995","journal-title":"J Immunol"},{"key":"e_1_2_18_72_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.2.757"},{"key":"e_1_2_18_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2315"},{"key":"e_1_2_18_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00274-1"},{"key":"e_1_2_18_75_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.1.241"},{"key":"e_1_2_18_76_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.14.3760"},{"key":"e_1_2_18_77_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.27.16357"},{"key":"e_1_2_18_78_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0104046"},{"key":"e_1_2_18_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2008.72"},{"key":"e_1_2_18_80_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.11.5578"},{"key":"e_1_2_18_81_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200837718"},{"key":"e_1_2_18_82_2","article-title":"An intracytoplasmic IL\u201010 receptor variant permits rapid reduction in STAT3 activation","author":"Finsterbusch M","journal-title":"Genes Immun"},{"key":"e_1_2_18_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364168"},{"key":"e_1_2_18_84_2","article-title":"IL\u201010RA truncation mutations and semite populations","author":"Gasche C","year":"2010","journal-title":"Inflamm Bowel Dis"},{"key":"e_1_2_18_85_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.9.5043"},{"key":"e_1_2_18_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.221"},{"key":"e_1_2_18_87_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.10.032"},{"key":"e_1_2_18_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.175"},{"key":"e_1_2_18_89_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.4.571"},{"key":"e_1_2_18_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.07.002"},{"key":"e_1_2_18_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/35079114"},{"key":"e_1_2_18_92_2","doi-asserted-by":"publisher","DOI":"10.1038\/35079107"},{"key":"e_1_2_18_93_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.09.009"},{"key":"e_1_2_18_94_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1823"},{"key":"e_1_2_18_95_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505256102"},{"key":"e_1_2_18_96_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104911"},{"key":"e_1_2_18_97_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1103685"},{"key":"e_1_2_18_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1722"},{"key":"e_1_2_18_99_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1863"},{"key":"e_1_2_18_100_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.10.6522"},{"key":"e_1_2_18_101_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006026"},{"key":"e_1_2_18_102_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905815106"},{"key":"e_1_2_18_103_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2711"},{"key":"e_1_2_18_104_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.10.3991-3996.2005"},{"key":"e_1_2_18_105_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.07.014"},{"key":"e_1_2_18_106_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.6.3143"},{"key":"e_1_2_18_107_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21404"},{"key":"e_1_2_18_108_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.6.2385-2396.2004"},{"key":"e_1_2_18_109_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.09.041"},{"key":"e_1_2_18_110_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.09.047"},{"key":"e_1_2_18_111_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20098"},{"key":"e_1_2_18_112_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00869.x"},{"key":"e_1_2_18_113_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.6.1047"},{"key":"e_1_2_18_114_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.4.2022"},{"key":"e_1_2_18_115_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001535"},{"key":"e_1_2_18_116_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.4.1695"},{"key":"e_1_2_18_117_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.683"},{"key":"e_1_2_18_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2005.01.016"},{"key":"e_1_2_18_119_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.5.3383"},{"key":"e_1_2_18_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2007.09.011"},{"key":"e_1_2_18_121_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26373"},{"key":"e_1_2_18_122_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2009.122"},{"key":"e_1_2_18_123_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.11.4529-4540.2005"},{"key":"e_1_2_18_124_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.309"},{"key":"e_1_2_18_125_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.10.030"},{"key":"e_1_2_18_126_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb07256.x"},{"key":"e_1_2_18_127_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.45.31868"},{"key":"e_1_2_18_128_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.4.2592"},{"key":"e_1_2_18_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2010.09.006"},{"key":"e_1_2_18_130_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.11.075"},{"key":"e_1_2_18_131_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701232"},{"key":"e_1_2_18_132_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200012)43:12<2660::AID-ANR5>3.0.CO;2-4"},{"key":"e_1_2_18_133_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200201001-00008"},{"key":"e_1_2_18_134_2","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.4049\/jimmunol.158.8.3971","article-title":"Attenuation of proinflammatory response by recombinant human IL\u201010 in human endotoxemia: effect of timing of recombinant human IL\u201010 administration","volume":"158","author":"Pajkrt D","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_18_135_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199710150-00012"},{"key":"e_1_2_18_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(99)00946-X"},{"key":"e_1_2_18_137_2","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1997.5109"},{"key":"e_1_2_18_138_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.85.8.e17"},{"key":"e_1_2_18_139_2","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2009.0095"},{"key":"e_1_2_18_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70134-X"},{"key":"e_1_2_18_141_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200011100-00012"},{"key":"e_1_2_18_142_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e31819777d5"},{"key":"e_1_2_18_143_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200110000-00010"},{"key":"e_1_2_18_144_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.03.028"},{"key":"e_1_2_18_145_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9247454"},{"key":"e_1_2_18_146_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.1.42"},{"key":"e_1_2_18_147_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.20196"},{"key":"e_1_2_18_148_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.2.191"},{"key":"e_1_2_18_149_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.4.2204"},{"key":"e_1_2_18_150_2","first-page":"449","article-title":"In vivo effects of recombinant human interleukin\u201010 on lymphocyte phenotypes and leukocyte activation markers in inflammatory bowel disease","volume":"48","author":"Dejaco C","year":"2000","journal-title":"J Investig Med"},{"key":"e_1_2_18_151_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.6"},{"key":"e_1_2_18_152_2","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2008.67"},{"key":"e_1_2_18_153_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5483.1352"},{"key":"e_1_2_18_154_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20346"},{"key":"e_1_2_18_155_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000037830.22065.71"},{"key":"e_1_2_18_156_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.7.981"},{"key":"e_1_2_18_157_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.06.018"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2362.2011.02552.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2362.2011.02552.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T07:54:48Z","timestamp":1698738888000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2362.2011.02552.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":156,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1111\/j.1365-2362.2011.02552.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2362.2011.02552.x","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}