{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:29:45Z","timestamp":1760027385855},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,11,3]],"date-time":"2011-11-03T00:00:00Z","timestamp":1320278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec><jats:label \/><jats:p>Eur J Clin Invest 2012; 42 (5): 541\u2013547<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> There is limited insight into the association of electrocardiographic interpretability with outcome in patients referred for stress testing.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Exercise echocardiography was performed in 8226 patients with known or suspected coronary artery disease. Electrocardiograms were considered uninterpretable in the presence of left bundle\u2010branch block (LBBB), left ventricular hypertrophy (LVH) with strain, repolarization abnormalities because of digitalis therapy, ventricular paced rhythm, preexcitation or ST depression \u2265\u20030\u00b71\u2003mV because of other causes. End points were all\u2010cause mortality, cardiac death and hard cardiac events (i.e. cardiac death or nonfatal myocardial infarction).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> A total of 2450 patients had uninterpretable electrocardiograms. During a follow\u2010up period of 4\u00b71\u2003\u00b1\u20033\u00b75\u2003years, there were 1011 deaths (of which 478 were cardiac deaths) and 1069 patients experienced a hard cardiac event. The 5\u2010year rates of death, cardiac death and hard cardiac events were, respectively, 18\u00b77%, 10\u00b79% and 18\u00b78% in patients with uninterpretable ECGs, compared with 9\u00b75%, 4\u00b71% and 10\u00b79% in those with interpretable ECGs (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b7001). After covariate adjustment, lack of ECG interpretability remained an independent predictor of all\u2010cause mortality (hazard ratio [HR] 1\u00b725, 95% confidence interval [CI] 1\u00b708\u20131\u00b744, <jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7002), cardiac death (HR 1\u00b763, 95% CI 1\u00b732\u20132\u00b701, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b7001) and hard cardiac events (HR 1\u00b728, 95% CI 1\u00b711\u20131\u00b747, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b7001). When the specific ECG abnormalities were included as covariates, LBBB, LVH and digitalis therapy remained predictors of cardiac death; LBBB and LVH were predictors of hard cardiac events, and LVH remained predictive of all\u2010cause mortality.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Uninterpretable ECGs portend a worse prognosis in patients referred for stress testing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2362.2011.02615.x","type":"journal-article","created":{"date-parts":[[2011,10,10]],"date-time":"2011-10-10T17:19:25Z","timestamp":1318267165000},"page":"541-547","source":"Crossref","is-referenced-by-count":8,"title":["Impact of electrocardiographic interpretability on outcome in patients referred for stress 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