{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:26:46Z","timestamp":1792301206594,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T00:00:00Z","timestamp":1323302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:sec><jats:label\/><jats:p>Eur J Clin Invest 2012; 42 (6): 631\u2013636<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold>Low\u2010density lipoprotein (LDL) cholesterol lowering has been established as one of the principal targets in preventive cardiology. Recently, assessment of LDL particle size and number as well as other lipid moieties has been presented as a more reliable method to quantify atherogenicity of the lipoprotein fractions. Thus, it was our aim to assess the influence of different lipoprotein fractions on premature myocardial infarction (\u2264\u200340\u2003years of age).<\/jats:p><jats:p><jats:bold>Methods and results\u2002<\/jats:bold>We enrolled 302 patients into our multicentre case\u2013control study, including 102 patients with myocardial infarction and 200 age\u2010, gender\u2010 and centre\u2010matched controls. The LDL and HDL Lipoprint<jats:sup><jats:bold>\u00ae<\/jats:bold><\/jats:sup>System were used for lipid subfraction quantification. The lipid risk factors most strongly associated with premature acute myocardial infarction (AMI) in the adjusted model were non\u2010HDL C (OR 5\u00b702, 95% CI 2\u00b775\u20139\u00b715,<jats:italic>P<\/jats:italic>\u2010value\u2003=\u20030\u00b7001), LDL\u2010C (OR 4\u00b735, 95% CI 2\u00b75\u20137\u00b757,<jats:italic>P<\/jats:italic>\u2010value\u2003=\u20030\u00b7001), VLDL\u2010C (OR 3\u00b766, 95% CI 2\u00b714\u20136\u00b728,<jats:italic>P<\/jats:italic>\u2010value\u2003=\u20030\u00b7001), large IDL\u2010C (OR 3\u00b715, 95% CI 1\u00b794\u20135\u00b712,<jats:italic>P<\/jats:italic>\u2010value\u2003=\u20030\u00b7001), large LDL\u2010C (OR 3\u00b767, 95% CI 2\u00b719\u20136\u00b715,<jats:italic>P<\/jats:italic>\u2010value\u2003=\u20030\u00b7001) and intermediate LDL\u2010C (OR 1\u00b796, 95% CI 1\u00b725\u20133\u00b706,<jats:italic>P<\/jats:italic>\u2010value\u2003=\u20030\u00b7003). In contrast, small dense LDL was not significantly associated with premature myocardial infarction.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold>Non\u2010HDL cholesterol is most strongly associated with premature coronary artery disease and could serve as preferred risk predictor and therapeutic target in this young patient population (\u2264\u200340\u2003years). Besides, VLDL, LDL\u2010C, large LDL, intermediate LDL and large IDL were significantly associated with premature myocardial infarction. Furthermore, our data suggest that risk prediction using small dense LDL particles might not be useful in young AMI survivors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2362.2011.02629.x","type":"journal-article","created":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T14:41:03Z","timestamp":1320936063000},"page":"631-636","source":"Crossref","is-referenced-by-count":59,"title":["Relative importance of different lipid risk factors for the development of myocardial infarction at a very young age (\u2264\u200340\u2003years of age)"],"prefix":"10.1111","volume":"42","author":[{"given":"Georg","family":"Goliasch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav","family":"Oravec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Blessberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Dostal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Hoke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Wojta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schillinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Maurer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Wiesbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,8]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.06.051"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00218-1"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-08-0529"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp051"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.106.25.3143"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-004-0050-5"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02632-2"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03540110029028"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.09.043"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.565135"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio0500"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02234.x"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.187397"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.03.062"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/47.2.266"},{"key":"e_1_2_9_17_2","first-page":"147","volume-title":"Modern Epidemiology","author":"Rothman K","year":"1998"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.143.1.7063747"},{"key":"e_1_2_9_19_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini Y","year":"1995","journal-title":"J Roy Stat Soc"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01626.x"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2002.00941.x"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.9.2146"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.11.2742"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.02.035"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2003.01125.x"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.1.129"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000183727.90611.4f"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.289.6459.1651"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2362.2011.02629.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2362.2011.02629.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T23:48:51Z","timestamp":1741909731000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2362.2011.02629.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,8]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1365-2362.2011.02629.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2362.2011.02629.x","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,8]]}}}