{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:45:40Z","timestamp":1776987940042,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,11,29]],"date-time":"2011-11-29T00:00:00Z","timestamp":1322524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:sec><jats:label\/><jats:p>Eur J Clin Invest 2012; 42 (6): 637\u2013648<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> This study was undertaken to evaluate the preventive effect of \u03b1\u2010lipoic acid (LA) on chronic mild portal endotoxaemia\u2010mediated subacute hepatic inflammation and pancreatic \u03b2 cell dysfunction in rats.<\/jats:p><jats:p><jats:bold>Materials and methods\u2002<\/jats:bold> Male Sprague\u2013Dawley rats were randomly assigned into four groups: those with intraportal vehicle (saline) or low\u2010dose lipopolysaccharide (LPS) (0\u00b742\u2003ng\/kg\/min) infusion, combined with oral administration of vehicle or LA, a potent antioxidant (60\u2003mg\/kg\/day) for 4\u2003weeks. The hyperglycaemic clamp and euglycaemic clamp techniques were used to access the glucose\u2010stimulated insulin secretion and systemic insulin sensitivity <jats:italic>in vivo<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Body weight, fasting plasma glucose and insulin were not different among groups. In rats with chronic intraportal LPS infusion, plasma C\u2010reactive protein, amylase, superoxide levels, the contents of thiobarbituric acid\u2010reactive substance, tumour necrosis factor \u03b1 and interleukin 6 in liver and pancreas and also the gene expression of Toll\u2010like receptor 4 in liver were significantly increased as compared with those with LA cotreatment. The histopathological examination showed that inflammatory changes were clearly visible in liver and pancreatic islets of LPS\u2010infused rats and rarely observed in those cotreated with LA. In addition, low\u2010dose intraportal LPS infusion also significantly impaired glucose\u2010stimulated insulin secretion but not affect the systemic insulin sensitivity and metabolic clearance rate of insulin. LA administration markedly reversed LPS\u2010induced \u03b2 cell dysfunction.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> \u03b1\u2010Lipoic acid cotreatment could significantly prevent mild portal endotoxaemia\u2010induced chronic hepatic inflammation and impaired pancreatic insulin secretion in absence of changing systemic insulin resistance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2362.2011.02630.x","type":"journal-article","created":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T08:04:03Z","timestamp":1321517043000},"page":"637-648","source":"Crossref","is-referenced-by-count":19,"title":["\u03b1\u2010Lipoic acid prevents mild portal endotoxaemia\u2010induced hepatic inflammation and \u03b2 cell dysfunction"],"prefix":"10.1111","volume":"42","author":[{"given":"Yu\u2010Feng","family":"Tian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Hsun","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen\u2010Ju","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Ting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Jen","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po\u2010Shiuan","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,29]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.04.019"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.2.206"},{"key":"e_1_2_9_4_2","first-page":"G1186","article-title":"Female rats exhibit greater susceptibility to early alcohol\u2010induced liver injury than males","volume":"272","author":"Iimuro Y","year":"1997","journal-title":"Am J Physiol"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1726-4901(09)70194-7"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.280"},{"key":"e_1_2_9_7_2","first-page":"31","article-title":"Prevalence and significance of type\u20102 diabetes mellitus in chronic liver disease, correlated with hepatitis C virus","volume":"18","author":"Brischetto R","year":"2003","journal-title":"Ann Ital Med Int"},{"key":"e_1_2_9_8_2","first-page":"201","article-title":"Exocrine pancreatic function in chronic liver diseases","volume":"86","author":"Hayakawa T","year":"1991","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2008.01991.x"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2008.01714.x"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2011.01.009"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2009.07.026"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2002.02755.x"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.481_4.x"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2006.06.004"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2008.02026.x"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1979.237.3.E214"},{"key":"e_1_2_9_18_2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.2337\/diab.38.6.673","article-title":"A new phase of insulin secretion. 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