{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:05:16Z","timestamp":1770833116128,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T00:00:00Z","timestamp":1332806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec><jats:label\/><jats:p>Eur J Clin Invest 2012; 42 (9): 921\u2013926<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Humoral mediators of inflammation, in particular the complement system, have been described to play an important role in atherogenesis. Previously, we found a single\u2010nucleotide polymorphism (SNP) in the complement 5 gene (<jats:italic>C5 rs17611, A&gt;G<\/jats:italic>) independently associated with stroke. Up to now, the impact of <jats:italic>C5 rs17611<\/jats:italic> on the progression of atherosclerosis and cardiovascular outcome in patients with asymptomatic atherosclerosis was unclear.<\/jats:p><jats:p><jats:bold>Materials and Methods\u2002<\/jats:bold> We investigated <jats:italic>C5 rs17611<\/jats:italic> in a cohort of 1065 consecutive patients with asymptomatic carotid atherosclerosis. All patients were prospectively followed for the progression of carotid atherosclerosis and the development of a first major cardiovascular event (MACE), respectively.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Three hundred and thirty\u2010seven patients (31\u00b76%) experienced a MACE during a median follow\u2010up of 3\u00b70\u2003years. The homozygous GG genotype of the <jats:italic>C5 rs17611<\/jats:italic> was significantly associated with adverse cardiovascular outcome (adjusted HR: 1\u00b736 [95% CI, 1\u00b707\u20131\u00b773]; <jats:italic>P<\/jats:italic>\u2003=\u20030\u00b701). After stratification for sex, <jats:italic>C5 rs17611<\/jats:italic> CC was found to be an independent risk factor for MACE in men (HR 1\u00b750 [95% CI, 1\u00b712\u20131\u00b783]). No association of <jats:italic>C5 rs17611<\/jats:italic> with progression of carotid stenosis, observed in 93 (8\u00b77%) patients, was detectable. Performance of ELISA indicated a significant association of the <jats:italic>C5 rs17611 variant<\/jats:italic> with C5a plasma levels.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The <jats:italic>C5 rs17611<\/jats:italic> GG genotype is associated with increased C5a plasma levels and represents a risk factor for adverse cardiovascular outcome in male patients with carotid atherosclerosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2362.2012.02669.x","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T15:54:45Z","timestamp":1330962885000},"page":"921-926","source":"Crossref","is-referenced-by-count":23,"title":["Polymorphism of the complement 5 gene and cardiovascular outcome in patients with 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