{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:19:15Z","timestamp":1783480755316,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T00:00:00Z","timestamp":1337212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec><jats:label\/><jats:p>Eur J Clin Invest 2012; 42 (10): 1121\u20131125<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Developmental dysplasia of the hip (DDH) is a developmental disorder of the hip joint that results in an abnormal socket of the femoral head, ranging from instability, subluxation and complete dislocation of the hip joint. DDH has a considerable genetic component.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> We reviewed the recent progress on genetic study of DDH.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> By linkage and case\u2013control association studies, DDH loci have been identified with several susceptibility genes that involve in bone and joint biology; however, no unequivocal genes with global significance have been detected. The current problem of the association study in DDH is discussed.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> By advanced technologies and international collaboration, we need to find more susceptibility genes and bridge the gap between genetic evidence and molecular mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2362.2012.02682.x","type":"journal-article","created":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T22:09:52Z","timestamp":1335305392000},"page":"1121-1125","source":"Crossref","is-referenced-by-count":36,"title":["Genetic study on developmental dysplasia of the 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