{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:25:01Z","timestamp":1791314701551,"version":"4.3.1"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,5,15]],"date-time":"2012-05-15T00:00:00Z","timestamp":1337040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec><jats:label\/><jats:p>Eur J Clin Invest 2012; 42 (9): 992\u2013999<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Postprandial hyperlipidemia partially refers to the postprandial accumulation of chylomicrons and chylomicron remnants (CM\u2010R). Many <jats:italic>in vitro<\/jats:italic> studies have shown that CM\u2010R has highly atherogenic properties, but consensus is lacking on whether CM\u2010R accumulation correlates with the development of atherosclerotic cardiovascular diseases. We investigated the correlation between CM\u2010R accumulation and the prevalence of coronary artery disease (CAD).<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Subjects who received a coronary angiography and did not take any lipid\u2010lowering drugs (<jats:italic>n<\/jats:italic>\u2003=\u2003189) were enrolled. Subjects with coronary artery stenosis (\u2265\u200375%) were diagnosed as CAD. Biochemical markers for glucose and lipid metabolism including fasting apolipoprotein (apo) B\u201048 concentration were compared between CAD patients (<jats:italic>n<\/jats:italic>\u2003=\u200396) and age\u2010, sex\u2010, and body mass index (BMI)\u2010matched non\u2010CAD subjects without overt coronary stenosis (&lt;\u200375%) (<jats:italic>n<\/jats:italic>\u2003=\u200367). We tried to determine which metabolic parameters were correlated with the prevalence of CAD by multiple logistic regression analysis, and whether or not the combination of high apo B\u201048 and other coronary risk factors (high triglyceride, low HDL\u2010C, high HbA1c or low adiponectin levels) increased the prevalence of CAD.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Fasting serum apo B\u201048 levels were significantly higher in CAD patients than in non\u2010CAD subjects (3\u00b79\u2003\u00b1\u20032\u00b74 vs. 6\u00b79\u2003\u00b1\u20032\u00b76\u2003\u03bcg\/mL, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b70001) and had the most significant correlation with the existence of CAD. The clustering of high fasting apo B\u201048 levels (&gt;\u20034\u00b734\u2003\u03bcg\/mL, the cut\u2010off value) and other coronary risk factors were found to be associated with a stronger risk of CAD compared with single high fasting apo B\u201048 levels.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Fasting serum apo B\u201048 levels significantly correlated with the prevalence of CAD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2362.2012.02687.x","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T17:30:18Z","timestamp":1334770218000},"page":"992-999","source":"Crossref","is-referenced-by-count":59,"title":["Correlation of fasting serum apolipoprotein B\u201048 with coronary artery disease 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