{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:59:57Z","timestamp":1763017197747},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,5,24]],"date-time":"2012-05-24T00:00:00Z","timestamp":1337817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec><jats:label \/><jats:p>Eur J Clin Invest 2012; 42 (10): 1047\u20131054<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> To compare clinical outcomes among patients with acute coronary syndrome treated with zotarolimus\u2010eluting and sirolimus\u2010eluting stents in the SORT OUT III trial.<\/jats:p><jats:p><jats:bold>Background:\u2002<\/jats:bold> Currently, only limited data allow direct comparison of clinical outcomes among patients with acute coronary syndrome treated with a second\u2010generation drug\u2010eluting stent (DES) eluting zotarolimus vs. a first\u2010generation DES eluting sirolimus.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Patients with acute coronary syndrome (<jats:italic>n<\/jats:italic>\u2003=\u20031052) were randomized to treatment with zotarolimus\u2010eluting (<jats:italic>n<\/jats:italic>\u2003=\u2003506) or sirolimus\u2010eluting (<jats:italic>n<\/jats:italic>\u2003=\u2003546) stents and followed for 18\u2003months. The primary composite endpoint, major adverse cardiac events (MACE), was defined as a composite of cardiac death, myocardial infarction or target vessel revascularization.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Zotarolimus\u2010eluting stent treatment compared to sirolimus\u2010eluting stent treatment was associated with increased rates of MACE (8\u00b77% vs. 5\u00b70%; hazard ratio (HR), 1\u00b778; 95% confidence interval (CI), 1\u00b710\u20132\u00b788; <jats:italic>P<\/jats:italic>\u2003=\u20030\u00b702) and TVR (6\u00b78% vs. 3\u00b79%; HR, 1\u00b777; 95% CI, 1\u00b703\u20133\u00b704; <jats:italic>P<\/jats:italic>\u2003=\u20030\u00b704), while all\u2010cause death, cardiac death, myocardial infarction and definite stent thrombosis did not differ significantly. In the same trial, stable angina pectoris patients (<jats:italic>n<\/jats:italic>\u2003=\u20031206) were randomized to zotarolimus\u2010eluting (<jats:italic>n<\/jats:italic>\u2003=\u2003614) and sirolimus\u2010eluting (<jats:italic>n<\/jats:italic>\u2003=\u2003592) stents with similar results.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> With and without acute coronary syndromes, patients treated with the sirolimus\u2010eluting stent had better clinical outcomes than those treated with the zotarolimus\u2010eluting stent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2362.2012.02692.x","type":"journal-article","created":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T21:37:48Z","timestamp":1335303468000},"page":"1047-1054","source":"Crossref","is-referenced-by-count":7,"title":["Zotarolimus\u2010eluting vs. sirolimus\u2010eluting coronary stents in patients with and without acute coronary syndromes: a SORT OUT III 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