{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:59:07Z","timestamp":1791071947330,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,8,25]],"date-time":"2012-08-25T00:00:00Z","timestamp":1345852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec><jats:label\/><jats:p>Eur J Clin Invest 2012; 42 (11): 1213\u20131220<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Chemerin is an adipokine that regulates insulin sensitivity and insulin secretion. Prolonged hyperinsulinaemia is associated with higher systemic chemerin, and insulin induces adipose tissue chemerin release. These findings led us to hypothesize that systemic chemerin may be associated with post\u2010prandial glucose metabolism and\/or may even be induced after oral glucose load. Therefore, the effect of insulin on adipocyte chemerin levels and systemic chemerin in mice was analysed. Further, systemic levels of chemerin after oral glucose load in nondiabetic individuals were studied.<\/jats:p><jats:p><jats:bold>Design and methods\u2002<\/jats:bold> Chemerin levels were determined in adipocytes after short\u2010term and long\u2010term treatment with insulin. Effects of acute hyperinsulinaemia were studied in mice. Chemerin was measured during oral glucose tolerance test in 66 healthy, nondiabetic individuals stratified for established body mass index categories.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Insulin induces chemerin release from adipocytes within 24\u2003h, while cellular levels are not affected. Short\u2010term hyperinsulinaemia also upregulates adipocyte chemerin <jats:italic>in vitro<\/jats:italic> but has no effect on adipose tissue and chemerin serum levels of mice. Systemic chemerin is higher in overweight\/obese than normal\u2010weight controls and positively correlates with total cholesterol. Chemerin is not associated with markers of insulin sensitivity like fasting glucose or insulin. Fasting chemerin levels are similar to concentrations measured 1 and 2\u2003h after oral glucose uptake in overweight and obese donors.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Post\u2010prandial hyperinsulinaemia does not contribute to higher chemerin levels in nondiabetic individuals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2362.2012.02713.x","type":"journal-article","created":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T06:49:54Z","timestamp":1343458194000},"page":"1213-1220","source":"Crossref","is-referenced-by-count":28,"title":["Adipocyte chemerin release is induced by insulin without being translated to higher levels <i>in vivo<\/i>"],"prefix":"10.1111","volume":"42","author":[{"given":"Sabrina","family":"Bauer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Bala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Kopp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Eisinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Neumeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa","family":"Buechler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,25]]},"reference":[{"key":"e_1_2_8_2_2","first-page":"2801","article-title":"Adiponectin, a key adipokine in obesity related liver diseases","volume":"17","author":"Buechler C","year":"2011","journal-title":"World J Gastroenterol"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2010.08.001"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.2119\/2008-00058.Rabe"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0175"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700793200"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0362"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0380"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03664.x"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0277"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1528"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1157"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2009.02.010"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep00123"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.01.023"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400953"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0342"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2011.10.006"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2011.19"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2011.11.004"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2362.2012.02713.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2362.2012.02713.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T21:40:58Z","timestamp":1698788458000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2362.2012.02713.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,25]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1365-2362.2012.02713.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2362.2012.02713.x","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,25]]}}}