{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:24:13Z","timestamp":1783128253869,"version":"3.54.6"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,9,23]],"date-time":"2012-09-23T00:00:00Z","timestamp":1348358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec><jats:label\/><jats:p>Eur J Clin Invest 2012; 42 (12): 1261\u20131271<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Increased angiotensin II (Ang II) plays an important role in liver inflammation and fibrogenesis. Chronic administration of aliskiren, a newly developed direct renin inhibitor, decreases Ang II in the hypertensive patients and animals.<\/jats:p><jats:p><jats:bold>Aims\u2002<\/jats:bold> Our study aims to evaluate the possible protective effects of chronic administration of aliskiren in a chronic liver injury model.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> C57BL6 mice were injected intraperitoneally with carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) to induce chronic liver injury. The injured mice were randomly assigned to aliskiren\u2010treated (25\u2003mg\/kg per day for 2\u2003weeks, the CCl<jats:sub>4<\/jats:sub>\u2003+\u2003Ali group) or untreated group (the CCl<jats:sub>4<\/jats:sub> group). Mice without CCl<jats:sub>4<\/jats:sub> and aliskiren administration served as the normal control.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> In the CCl<jats:sub>4<\/jats:sub>\u2010injured mice, aliskiren attenuated liver inflammation and fibrosis. The levels of hepatocyte apoptosis, lipid peroxidation production, the activation of hepatic stellate cells and Kupffer cells, hepatic expression of p47 phox, inflammatory mediators and profibrotic markers were reduced in the CCl<jats:sub>4<\/jats:sub>\u2003+\u2003Ali group. Furthermore, aliskiren decreased Ang II, activated the renal expression of renin, but down\u2010regulated the hepatic expression of renin and renin receptor in the CCl<jats:sub>4<\/jats:sub>\u2010injected mice.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Aliskiren attenuates chronic liver injury in the CCl<jats:sub>4<\/jats:sub>\u2010treated mice by reducing Ang II. Direct renin inhibition may serve as a potential treatment for chronic liver injury.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2362.2012.02725.x","type":"journal-article","created":{"date-parts":[[2012,8,29]],"date-time":"2012-08-29T16:06:13Z","timestamp":1346256373000},"page":"1261-1271","source":"Crossref","is-referenced-by-count":12,"title":["Aliskiren attenuates chronic carbon tetrachloride\u2013induced liver injury in 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