{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:39:23Z","timestamp":1790127563017,"version":"4.0.1"},"reference-count":58,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,7,10]],"date-time":"2006-07-10T00:00:00Z","timestamp":1152489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p> <jats:italic>PAX6\/Pax6<\/jats:italic> gene encodes a transcription factor that is crucially required for eye development. Pax6 heterozygous mutant mouse (<jats:italic>Pax6<\/jats:italic><jats:sup><jats:italic>Sey<\/jats:italic>\/+<\/jats:sup>) shows various ocular defects, especially in the anterior segment. It has been well known that the induction of the lens and development of the cornea and retina are dependent on <jats:italic>PAX6\/Pax6<\/jats:italic> in a cell\u2010autonomous fashion, although the influence of <jats:italic>PAX6\/Pax6<\/jats:italic> on the other tissues derived from the ocular mesenchyme is largely unknown. Using transgenic mouse lines in which neural crest cells are genetically marked by LacZ or EGFP, we revealed the extensive contribution of neural crest derived cells (NCDCs) to the ocular tissues. Furthermore, various eye defects in <jats:italic>Pax6<\/jats:italic><jats:sup><jats:italic>Sey<\/jats:italic>\/+<\/jats:sup> mouse were accompanied by abnormal distribution of NCDCs from early developmental stages to the adult. In <jats:italic>Pax6<\/jats:italic><jats:sup><jats:italic>Sey<\/jats:italic>\/+<\/jats:sup> mouse mice, neural crest cells abnormally migrated into the developing eye in a cell nonautonomous manner at early embryonic stages. These results indicate that normal distribution and integration of NCDCs in ocular tissues depend on a proper dosage of Pax6, and that <jats:italic>Pax6<\/jats:italic><jats:sup><jats:italic>Sey<\/jats:italic>\/+<\/jats:sup> eye anomalies are caused by cell autonomous and nonautonomous defects due to <jats:italic>Pax6<\/jats:italic> haploinsufficiency.<\/jats:p>","DOI":"10.1111\/j.1365-2443.2006.00992.x","type":"journal-article","created":{"date-parts":[[2006,7,10]],"date-time":"2006-07-10T16:06:05Z","timestamp":1152547565000},"page":"919-933","source":"Crossref","is-referenced-by-count":68,"title":["Abnormal migration and distribution of neural crest cells in Pax6 heterozygous mutant eye, a model for human eye diseases"],"prefix":"10.1111","volume":"11","author":[{"given":"Sachiko","family":"Kanakubo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken\u2010ichi","family":"Yamamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010ichi","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Tamai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Osumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2512-05.2005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/375555"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(02)00260-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.8.1671"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2443.2002.00602.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-1118"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.041937sc"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20009"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(07)00562-3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi231"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.7.1059"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-0436.1994.5710031.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0894-463"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(74)90308-0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.5.1433"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0294-168"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(00)89073-3"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.012264999"},{"key":"e_1_2_6_20_1","first-page":"1","article-title":"Origin and distribution of collagens in the developing avian cornea","volume":"1","author":"Hay E.D.","year":"1979","journal-title":"Curr. 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