{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:12:20Z","timestamp":1778854340757,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,6,6]],"date-time":"2007-06-06T00:00:00Z","timestamp":1181088000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>The gene encoding the protein known as \u201ccorticosteroids and regional expression 16\u201d (CR16) has been shown to be regulated by glucocorticoids. CR16 is a member of the Wiskott\u2013Aldrich syndrome protein (WASP)\u2010interacting protein (WIP) family. It binds to the neural WASP (N\u2010WASP), which activates the Arp2\/3 complex to induce actin polymerization. CR16 is highly expressed in the testes, particularly in the Sertoli cells, which harbor sperm progenitors and play an important role in spermatogenesis. We found male\u2010specific sterility in the <jats:italic>CR16<\/jats:italic>\u2010knockout mice. The sperms of the <jats:italic>CR16<\/jats:italic>\u2010knockout mice had abnormal head morphology, and greatly diminished fertilization ability in<jats:italic> in vitro<\/jats:italic> fertilization experiments. CR16 and N\u2010WASP were localized to the actin filaments at the Sertoli cell\u2013spermatid junctions (SspJs). The level of N\u2010WASP but not the transcript was decreased in the testes and Sertoli cells of the <jats:italic>CR16<\/jats:italic>\u2010knockout mice. Therefore, CR16 and N\u2010WASP are suggested to play important roles in spermatogenesis.<\/jats:p>","DOI":"10.1111\/j.1365-2443.2007.01088.x","type":"journal-article","created":{"date-parts":[[2007,6,6]],"date-time":"2007-06-06T19:29:27Z","timestamp":1181158167000},"page":"721-733","source":"Crossref","is-referenced-by-count":22,"title":["Male\u2010specific sterility caused by the loss of CR16"],"prefix":"10.1111","volume":"12","author":[{"given":"Shiro","family":"Suetsugu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshibumi","family":"Banzai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoko","family":"Fukami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimi","family":"Takai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuaki","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadaomi","family":"Takenawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00268-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2002.5576"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.8.2865-2873.2000"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/44860"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200210057"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1242\/jcs.93.2.309","article-title":"Sertoli cell ectoplasmic specializations: a type of actin\u2010associated adhesion junction?","volume":"93","author":"Grove B.D.","year":"1989","journal-title":"J. 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