{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T06:10:48Z","timestamp":1698732648625},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T00:00:00Z","timestamp":1329782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes to Cells"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>The xeroderma pigmentosum group F\u2010cross\u2010complementing rodent repair deficiency group 1 (XPF\u2010ERCC1) complex is a structure\u2010specific endonuclease involved in nucleotide excision repair (NER) and interstrand cross\u2010link (ICL) repair. Patients with <jats:italic>XPF<\/jats:italic> mutations may suffer from two forms of xeroderma pigmentosum (XP): XP\u2010F patients show mild photosensitivity and proneness to skin cancer but rarely show any neurological abnormalities, whereas XFE patients display symptoms of severe XP symptoms, growth retardation and accelerated aging. <jats:italic>Xpf<\/jats:italic> knockout mice display accelerated aging and die before weaning. These results suggest that the XPF\u2010ERCC1 complex has additional functions besides NER and ICL repair and is essential for development and growth. In this study, we show a partial colocalization of XPF with mitotic spindles and Eg5. XPF knockdown in cells led to an increase in the frequency of abnormal nuclear morphology and mitosis. Similarly, the frequency of abnormal nuclei and mitosis was increased in XP\u2010F and XFE cells. In addition, we showed that Eg5 enhances the action of XPF\u2010ERCC1 nuclease activity. Taken together, these results suggest that the interaction between XPF and Eg5 plays a role in mitosis and DNA repair and offer new insights into the pathogenesis of XP\u2010F and XFE.<\/jats:p>","DOI":"10.1111\/j.1365-2443.2012.01582.x","type":"journal-article","created":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T10:41:45Z","timestamp":1329820905000},"page":"173-185","source":"Crossref","is-referenced-by-count":6,"title":["Xeroderma pigmentosum group F protein binds to Eg5 and is required for proper mitosis: implications for XP\u2010F and XFE"],"prefix":"10.1111","volume":"17","author":[{"given":"Li Jing","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Saijo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Kuraoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Narita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiaki","family":"Takahata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigenori","family":"Iwai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90142-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi026716j"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"7822","DOI":"10.1523\/JNEUROSCI.18-19-07822.1998","article-title":"Expression of the mitotic motor protein Eg5 in postmitotic neurons: implications for neuronal development","volume":"18","author":"Ferhat L.","year":"1998","journal-title":"J. Neurosci."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2006.05.005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.07.029"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/512486"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000337200"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.14.7835"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000876"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.039"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1883"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05456"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2011.07.005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.10.4289"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90253-5"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80155-5"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.3.1200-1205.2004"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.22.6370"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.100396"},{"key":"e_1_2_6_21_1","first-page":"121","article-title":"The TFIIH subunit p89 (XPB) localizes to the centrosome during mitosis","volume":"32","author":"Weber A.","year":"2010","journal-title":"Cell Oncol."},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(06)00190-4"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2005.12.018"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.07.024"}],"container-title":["Genes to Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2443.2012.01582.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2443.2012.01582.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T11:04:09Z","timestamp":1698663849000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2443.2012.01582.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,21]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1111\/j.1365-2443.2012.01582.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2443.2012.01582.x","archive":["Portico"],"relation":{},"ISSN":["1356-9597","1365-2443"],"issn-type":[{"value":"1356-9597","type":"print"},{"value":"1365-2443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,21]]}}}