{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T17:08:33Z","timestamp":1773940113474,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,4,14]],"date-time":"2004-04-14T00:00:00Z","timestamp":1081900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Of the six types of dual coagulation factors deficiency, combined factors V and VIII are the most common type, a few cases of this disease have been reported in different populations. This accounts for the relatively low number of cases reported so far. Our report, which included 19 patients, is the second largest group that has been reported from one centre in north\u2010eastern Iran. The most frequent spontaneous bleeding symptoms were epistaxis and haemarthrosis, and the most frequent traumatic bleeding symptoms were bleeding after dental extraction and bleeding after cutting any part of the body. It seemed that dual coagulation FV and FVIII deficiency is as severe as single coagulation factor (V or VIII) deficiency.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2004.00890.x","type":"journal-article","created":{"date-parts":[[2004,4,14]],"date-time":"2004-04-14T13:17:38Z","timestamp":1081948658000},"page":"271-275","source":"Crossref","is-referenced-by-count":43,"title":["Haemorrhagic symptoms in patients with combined factors V and VIII deficiency in north\u2010eastern Iran"],"prefix":"10.1111","volume":"10","author":[{"given":"H.","family":"Mansouritorgabeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Rezaieyazdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Pourfathollah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Rezai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Esamaili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,4,14]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199607)52:3<229::AID-AJH19>3.0.CO;2-A"},{"key":"e_1_2_8_3_2","first-page":"575","article-title":"Angeborener mangel an faktor V(parahaemophilie) verbunden mit echter haemophilie A bein zwei burden","volume":"1","author":"Oeri J","year":"1954","journal-title":"Med Probl Paediatr"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2000.00421.x"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198211043071907"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00620.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1998.440677.x"},{"key":"e_1_2_8_8_2","first-page":"151","article-title":"Hereditary combined coagulation factor V and factor VIII deficiency: report of two Indian families from Varanasi","volume":"45","author":"Shukla J","year":"2000","journal-title":"Indian J Pathol Microbiol"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002770000283"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000206867"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109952"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119193"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110725"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(84)90219-6"},{"key":"e_1_2_8_15_2","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1182\/blood.V62.6.1266.1266","article-title":"Normal titer of functional and immunoreactive protein C inhibitor in plasma of patients with congenital combined deficiency of factor V and factor VIII","volume":"62","author":"Suzuki K","year":"1983","journal-title":"Blood"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81146-0"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119201"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000208020"},{"key":"e_1_2_8_19_2","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1182\/blood.V93.7.2253","article-title":"Molecular analysis of the ERGIC\u201053 gene in 35 families with combined factor V\u2013factor VIII deficiency","volume":"93","author":"Neerman\u2010Arbez M","year":"1999","journal-title":"Blood"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1153"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2516.2004.00890.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2516.2004.00890.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T05:47:03Z","timestamp":1697176023000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2516.2004.00890.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4,14]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1111\/j.1365-2516.2004.00890.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2516.2004.00890.x","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4,14]]}}}