{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:28:06Z","timestamp":1762874886954},"reference-count":16,"publisher":"Wiley","issue":"s4","license":[{"start":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T00:00:00Z","timestamp":1097193600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold>  \n          von Willebrand disease is the most common inherited bleeding disorder in humans. VWD can be classified into three major types, designated Types 1, 2 and 3; Type 2 can be further separated into subtypes 2A, 2B, 2M and 2N. The diagnosis of VWD requires a personal and family history of bleeding and confirmation by laboratory analysis. Although Types 2 and 3 are relatively straightforward to diagnose, there may be a risk of overdiagnosis of Type 1 because of an overlap within the normal range. We also report on the clinical profile and diagnosis of VWD in a South American cohort of patients and on the <jats:italic>in vitro<\/jats:italic> characteristics of some factor concentrates available for treatment of VWD.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2004.00979.x","type":"journal-article","created":{"date-parts":[[2004,10,8]],"date-time":"2004-10-08T16:04:19Z","timestamp":1097251459000},"page":"164-168","source":"Crossref","is-referenced-by-count":24,"title":["von Willebrand disease: laboratory aspects of diagnosis and treatment"],"prefix":"10.1111","volume":"10","author":[{"given":"E. 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