{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T13:47:10Z","timestamp":1764078430061},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,9,2]],"date-time":"2004-09-02T00:00:00Z","timestamp":1094083200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold>This retrospective, open\u2010label, non\u2010comparative study evaluated continuous infusion of recombinant factor VIII (ReFacto\u00ae), B\u2010domain deleted recombinant FVIII (BDDrFVIII), in patients with haemophilia A undergoing surgery and requiring &gt;5 consecutive days of treatment. Sixteen patients from eight centres underwent a total of 20 procedures. Haemostatic outcome was assessed as \u2018excellent\u2019 or \u2018good\u2019 in 75% of procedures, and target FVIII:C levels were maintained throughout the continuous infusion period. The reported volume of blood loss during surgery was also within the normal range for non\u2010haemophilic patients for the type of surgery performed. Red blood cell transfusions were required to balance excessive blood loss during BDDrFVIII continuous infusion in eight (40%) procedures (seven patients), five with bleeding or requiring volume replacement and three to treat anaemia secondary to blood loss. Non\u2010serious adverse events considered by investigators as possibly or probably related to BDDrFVIII continuous infusion were infrequent (<jats:italic>n<\/jats:italic>\u2003=\u20035) considering the duration of treatment (<jats:italic>n<\/jats:italic>\u2003=239 cumulative days of continuous infusion), and all of these were mild\u2010to\u2010moderate in severity. No thromboembolic complications were reported except for one case of thrombophlebitis occurring at the infusion site. Only two patients (four events) experienced serious adverse bleeding; BDDrFVIII was otherwise well\u2010tolerated. These data show that continuous infusion of BDDrFVIII provides reliable haemostasis and is an effective and well\u2010tolerated regimen for patients with haemophilia A undergoing surgery.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2004.01013.x","type":"journal-article","created":{"date-parts":[[2004,9,7]],"date-time":"2004-09-07T13:49:52Z","timestamp":1094564992000},"page":"452-458","source":"Crossref","is-referenced-by-count":28,"title":["Continuous infusion of B\u2010domain deleted recombinant factor VIII (ReFacto) in patients with haemophilia A undergoing surgery: clinical experience"],"prefix":"10.1111","volume":"10","author":[{"given":"N.","family":"Stieltjes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Altisent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Auerswald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"N\u00e9grier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Pouzol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Reynaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Roussel\u2010Robert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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