{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T14:35:34Z","timestamp":1793889334328,"version":"4.8.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,1,21]],"date-time":"2005-01-21T00:00:00Z","timestamp":1106265600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Although prophylactic treatment is advised for all children with severe haemophilia, the optimal regimen is still under discussion. Should all joint bleeds be prevented, or can a limited amount of arthropathy be tolerated in adulthood without loss of quality of life? To answer this question, the effect of haemophilic arthropathy on health\u2010related quality of life (HRQoL) needs to be quantified. In a retrospective study, the effect of arthropathy on HRQoL and socio\u2010economic parameters was assessed in a single\u2010centre cohort of 96 patients with severe and moderate haemophilia with a minimum age of 13\u2003years. Arthropathy was measured by the radiological Pettersson score of the elbows, knees and ankles (maximum: 78 points). HRQoL was assessed by the Short Form 36 (SF36), measuring eight domains of health. Labourforce participation and medical consumption were assessed using a separate questionnaire. Patients were studied at a mean age of 28.6\u2003years (range: 13\u201354), the mean time between evaluation and the last Pettersson score was 0.4\u2003years (SD: 1.1). The overall median Pettersson score was 13 (range: 0\u201378). There was a trend towards lower quality of life with increasing Pettersson scores and age, especially in the physical domains of the SF36. An age\u2010adjusted analysis showed that arthropathy had a small but significant effect on HRQoL in the domain of \u2018physical function\u2019 of the SF36, but not on its other domains, or on labourforce participation and medical consumption. Thus suggesting that the SF36 can be used to assess the effects of haemophilic arthropathy, especially in the domain of \u2018physical function\u2019.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2005.01065.x","type":"journal-article","created":{"date-parts":[[2005,1,21]],"date-time":"2005-01-21T16:35:58Z","timestamp":1106325358000},"page":"43-48","source":"Crossref","is-referenced-by-count":93,"title":["Effects of haemophilic arthropathy on health\u2010related quality of life and socio\u2010economic parameters"],"prefix":"10.1111","volume":"11","author":[{"given":"K.","family":"Fischer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G.","family":"van der Bom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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