{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:51:20Z","timestamp":1761540680853},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,5]],"date-time":"2006-01-05T00:00:00Z","timestamp":1136419200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Prophylaxis with von Willebrand factor (VWF)\u2010containing concentrates is considered to be a potential approach for patients with von Willebrand disease (VWD) and severe bleeding tendency. We report the case of a 57\u2010year\u2010old man with type 3 VWD and a history of recurrent melaena. Bleeding frequency and severity had progressively increased and the patient showed chronic anaemia and persistent haemoglobin in the stools. Endoscopic examinations revealed multiple vascular mucosal abnormalities (MVA) of the stomach and large bowel. Photocoagulation of some actively bleeding lesions and octreotide did not significantly affect his clinical conditions: six red cell transfusions and &gt;400\u2003000\u2003IU of intermediate\u2010purity factor VIII (FVIII) concentrate (Haemate P) on\u2010demand were needed during 2002. Prophylaxis with Haemate P 40\u2003IU\u2003kg<jats:sup>\u22121<\/jats:sup> (102\u2003IU\u2003kg<jats:sup>\u22121<\/jats:sup> VWF:RCo) thrice weekly was associated with improvement of his mean haemoglobin levels, cessation of clear\u2010cut melaena and red cell transfusions and reduction of total Haemate P requirements (\u221220% over 2003\u201304). Prophylaxis with Haemate P is still ongoing without any adverse event over a 30\u2010month period. Clinical course and pharmacokinetic evaluations led to administer Haemate P each 72\u201396\u2003h. Possible vascular complications were excluded by a careful clinical follow up, as the patient suffered from arterial hypertension and diabetes mellitus; thrombophilic abnormalities were previously excluded and no signs of abnormal coagulation activation or FVIII:C levels &gt;150% were detected thereafter. Long\u2010term prophylaxis with Haemate P has been shown to be safe, effective (also in terms of quality of life) and cost saving in this patient with severe gastrointestinal bleeding due to MVA and VWD.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2006.01184.x","type":"journal-article","created":{"date-parts":[[2006,1,5]],"date-time":"2006-01-05T17:33:05Z","timestamp":1136482385000},"page":"90-94","source":"Crossref","is-referenced-by-count":10,"title":["Long\u2010term prophylaxis with intermediate\u2010purity factor VIII concentrate (Haemate P) in a patient with type 3 von Willebrand disease and recurrent gastrointestinal bleeding"],"prefix":"10.1111","volume":"12","author":[{"given":"A.","family":"COPPOLA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"CIMINO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"CONCA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"De Simone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"TUFANO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"TARANTINO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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