{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T19:43:08Z","timestamp":1767901388255,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,2,13]],"date-time":"2006-02-13T00:00:00Z","timestamp":1139788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Inhibitors represent one major complication of haemophilia treatment, as they increase the risk of bleeding, physical disability and mortality. The <jats:italic>Cost Of Care Inhibitors Study<\/jats:italic> (COCIS) showed that modern strategies applied to manage patients with inhibitors adsorb high amounts of resources but provide satisfactory levels of Health\u2010Related Quality\u2010of\u2010Life (HR\u2010QoL). This paper focuses on determinants of HR\u2010QoL in inhibitory patients. Fifty adult patients, enrolled by 11 Italian Haemophilia Centres, were clinically assessed and filled in two HR\u2010QoL generic questionnaires: the EuroQol instrument (EQ\u20105D) and the Short Form\u201036 (SF\u201036). According to our results, bleeding frequency and inhibitor titres were not found associated with HR\u2010QoL. Global HR\u2010QoL, and in particular the physical component of wellbeing in these patients was found negatively associated with their orthopaedic condition: the EQ\u20105D Visual Analogue Scale (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) scores, the SF\u201036 domain \u2018physical functioning\u2019 and \u2018physical component summary\u2019 (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01) scores were found significantly correlated with the orthopaedic joint score, even after adjusting for patients\u2019 age. These results were confirmed by those from the EQ\u20105D profile. To conclude, the COCIS study is the first study showing that HR\u2010QoL in inhibitory patients is impaired by their orthopedic status, while other aspects do not seem to influence patients\u2019 global wellbeing. Our results suggest that while the management of this complication is satisfactory, the attention has now to be focused on the prevention of the orthopaedic problems in these patients, which nowadays constitute one of the most important aspects to be considered in the haemophilia care.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2006.01204.x","type":"journal-article","created":{"date-parts":[[2006,2,13]],"date-time":"2006-02-13T15:11:02Z","timestamp":1139843462000},"page":"154-162","source":"Crossref","is-referenced-by-count":130,"title":["Quality of life is associated to the orthopaedic status in haemophilic patients with inhibitors"],"prefix":"10.1111","volume":"12","author":[{"given":"L.","family":"SCALONE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. G.","family":"MANTOVANI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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