{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:01:23Z","timestamp":1777960883087,"version":"3.51.4"},"reference-count":71,"publisher":"Wiley","issue":"s3","license":[{"start":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T00:00:00Z","timestamp":1146096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Considerable progress has been made in the past decade in describing the obstetrical and gynaecological aspects of von Willebrand's disease (VWD). In addition, epidemiological studies have established an approximately 11\u201316% prevalence of the laboratory diagnosis of VWD in women presenting with menorrhagia. However, it is not established presently whether an upfront VWD screening should be a part of the standard evaluation of menorrhagia. This is because it is presently not known whether therapy in the VWD patient tailored specifically for VWD will appreciably alter the natural history of menorrhagia compared with the non\u2010VWD menorrhagia patient. There are also subtleties involved in securing the diagnosis of VWD in women presenting with menorrhagia in terms of fluctuation of von Willebrand factor (VWF) levels vis\u2010\u00e0\u2010vis the menstrual cycle and the potential impact of oral contraceptive on VWF levels. Regarding management of VWD\u2010related menorrhagia, pending ongoing comparative trials of intranasal desmopressin (DDAVP), tranexamic acid, oral contraceptive and the levonorgestrel intrauterine device, specific recommendations cannot be made presently regarding the superiority of one intervention compared with the other. The management of VWD\u2010related postpartum haemorrhage is also an area of active debate in terms of \u2018best practice\u2019 in type 1 (? prophylactic DDAVP), type 2 [? expectant management if factor VIII:C (FVIII:C) level normalizes] and type 3 patients (? intensity and duration of infusional therapy with a VWF\u2010containing plasma\u2010derived FVIII concentrate). This review summarizes the present state of knowledge and highlights numerous questions for future study based on our present understanding of VWD in women.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2006.01272.x","type":"journal-article","created":{"date-parts":[[2006,4,28]],"date-time":"2006-04-28T08:36:36Z","timestamp":1146213396000},"page":"143-151","source":"Crossref","is-referenced-by-count":28,"title":["Current understanding of von Willebrand's disease in women \u2013 some answers, more questions"],"prefix":"10.1111","volume":"12","author":[{"given":"P. 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