{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:34:09Z","timestamp":1773203649457,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"s3","license":[{"start":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T00:00:00Z","timestamp":1146096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Prophylaxis is defined as primary (started before the onset of joint damage) or secondary (started after the onset of joint damage). The aim of primary prophylaxis is to prevent recurrent bleeding into joints and the development of chronic arthropathy in later life. When started early, and at most after two joint bleeds, the result is predictably excellent if there is compliance with the primary prophylaxis regimen. In order to decrease the need for central venous access devices to assure reliable venous access, a number of centres start primary prophylaxis with once weekly infusions with dose\u2010escalation based on frequency of joint bleeding. A major unanswered question is whether primary prophylaxis can be safely discontinued in adolescents\/young adults and if so, when. A promising predictor for the milder bleeding phenotype in persons with severe haemophilia is a later onset of joint bleeding. Once joint damage has occurred as a result of recurrent bleeding, secondary prophylaxis can only retard, but not prevent, ongoing joint damage. Other strategies to decrease recurrent bleeding from target joints include surgical synovectomy (ideally performed using an arthroscopic technique), radionuclide synovectomy and chemical synovectomy. These interventions have very good outcomes when performed by an experienced team. Given the very high cost of factor concentrates required for programmes of prophylaxis prospective studies that document benefits to the child and family, e.g. quality of life are to be encouraged.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2006.01281.x","type":"journal-article","created":{"date-parts":[[2006,4,28]],"date-time":"2006-04-28T08:36:36Z","timestamp":1146213396000},"page":"159-168","source":"Crossref","is-referenced-by-count":39,"title":["Prevention and treatment of musculoskeletal disease in the haemophilia population: role of prophylaxis and synovectomy"],"prefix":"10.1111","volume":"12","author":[{"given":"H. M.","family":"VAN DEN BERG","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"DUNN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"FISCHER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. S.","family":"BLANCHETTE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.9.s1.17.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1999.00328.x"},{"key":"e_1_2_6_4_2","first-page":"62","article-title":"International Forum. Prophylactic treatment of patients with haemophilia A or haemophilia B","volume":"88","author":"Yoshioka A","year":"2005","journal-title":"Vox Sang"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.01045.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01841.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-200010000-00003"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197759030-00001"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.00608.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00899.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1182\/blood.V104.11.42.42","article-title":"A role for angiogenesis in hemophilic synovitis","volume":"104","author":"Acharya SS","year":"2004","journal-title":"Blood"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310910"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.80B3.7807"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00704252"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01268.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03369"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1992.tb00546.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1997.130135000.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01463.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2001.00471.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00943.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.6.1727"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00653.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1998.440413.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.420960.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.7.2337"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01124.x"},{"issue":"1","key":"e_1_2_6_28_2","first-page":"219","article-title":"Final results from the Canadian hemophilia dose escalation prophylaxis trial","volume":"1","author":"Feldman B","year":"2003","journal-title":"J Thromb Haemost"},{"key":"e_1_2_6_29_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1182\/blood.V106.11.3.3","article-title":"Initial results of a randomized prospective trial of prophylaxis to prevent joint disease in young children with factor VIII (FVIII) deficiency","volume":"106","author":"Manco\u2010Johnson MJ","year":"2005","journal-title":"Blood"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1351-8216.2001.00120.x"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00560.x"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1994.tb00815.x"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1973.tb01680.x"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05546.x"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2000.00358.x"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00998.x"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00694.x"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830470209"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.9.s1.12.x"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198668020-00006"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1994.tb01066.x"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200309000-00010"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-200407000-00013"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1053\/jars.2002.32621"},{"key":"e_1_2_6_45_2","doi-asserted-by":"crossref","first-page":"482","DOI":"10.2106\/00004623-199404000-00002","article-title":"Synoviorthesis with colloidal 32P chromic phosphate for the treatment of hemophilic arthropathy","volume":"76","author":"Rivard GE","year":"1994","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200111000-00054"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200210000-00007"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01175.x"},{"key":"e_1_2_6_49_2","volume-title":"MASAC Recommendations Regarding Radionuclide Synovectomy","author":"National Hemophilia Foundation"},{"key":"e_1_2_6_50_2","first-page":"1","article-title":"Chronic hemophilic synovitis: the role of radiosynovectomy. Treatment of Hemophilia","volume":"33","author":"Silva M.","year":"2004","journal-title":"World Fed Hemophilia"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613015"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.01035.x"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.rlu.0000134978.24797.3c"},{"key":"e_1_2_6_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01447.x"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199710000-00007"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1999.00034.x"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01096.x"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00580.x"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00695.x"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2003.00817.x"},{"key":"e_1_2_6_61_2","first-page":"1","author":"Stobart K","year":"2005","journal-title":"Clotting Factor Concentrates Given to Prevent Bleeding and Bleeding-related Complications in People with Hemophilia A or B (Review)"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2516.2006.01281.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2516.2006.01281.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T04:21:35Z","timestamp":1695702095000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2516.2006.01281.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,27]]},"references-count":60,"journal-issue":{"issue":"s3","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1111\/j.1365-2516.2006.01281.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2516.2006.01281.x","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,27]]}}}