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Regular rinsing of the CVAD with heparin, according to a standard protocol, resulted in systemic anticoagulation, as demonstrated by prolonged thrombin time and therapeutic anti\u2010Xa levels. The bleeding symptoms resolved after replacing heparin with a normal saline solution. This case illustrates that heparin administered to maintain CVAD patency should be used with caution in young haemophiliacs. Prolonged thrombin time should alert the physician to this possible CVAD complication.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2006.01294.x","type":"journal-article","created":{"date-parts":[[2006,8,15]],"date-time":"2006-08-15T09:19:39Z","timestamp":1155633579000},"page":"548-550","source":"Crossref","is-referenced-by-count":4,"title":["Inadvertent anticoagulation of a haemophiliac child with routine line flushing"],"prefix":"10.1111","volume":"12","author":[{"given":"C.","family":"LAMBERT","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"DENEYS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"POTHEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"VERMYLEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"HERMANS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,15]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00943.x"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200309000-00008"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2003.00692.x"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2003.00840.x"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02184.x"},{"key":"e_1_2_4_7_2","unstructured":"MASAC.MASAC recommendations regarding central venous access devices included ports and passports.MASAC 2001. 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