{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:51:42Z","timestamp":1761540702916},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,6,23]],"date-time":"2006-06-23T00:00:00Z","timestamp":1151020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> This paper reports a new dysfibrinogenemia with an unusual pattern of laboratory assays. The patient, a 51\u2010year\u2010old female with a lifelong moderate bleeding history, was initially diagnosed with von Willebrand disease based on routine coagulation assays and the clinical bleeding presentation. During recent testing as part of a preoperative screen and without any current history of treatment, levels of von Willebrand factor (VWF) antigen, VWF activity, and factor VIII activity were all significantly elevated, which was unexpected given her previous diagnosis. Additional testing was performed looking for other heritable causes for her considerable bleeding tendency. Interestingly, the patient had a significantly prolonged Reptilase time, minimally short thrombin time, and an abnormal fibrinogen\u2010crossed immunoelectrophoresis pattern. Clearly, this patient had a fibrinogen abnormality that had been missed when only routine coagulation screening assays were performed. A brief review of the fibrinogen literature revealed no other dysfibrinogenemias reported with a similar pattern of test results, and thus this defect was designated fibrinogen Denver.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2006.01300.x","type":"journal-article","created":{"date-parts":[[2006,6,23]],"date-time":"2006-06-23T14:55:42Z","timestamp":1151074542000},"page":"393-397","source":"Crossref","is-referenced-by-count":6,"title":["Fibrinogen Denver: a dysfibrinogenemia associated with an abnormal Reptilase time and significant bleeding"],"prefix":"10.1111","volume":"12","author":[{"given":"S.","family":"WALTER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"STABLER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. B.","family":"LEFKOWITZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,23]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"203","volume-title":"Hemostasis and Thrombosis: Basic Principles and Clinical Practice","author":"McDonagh J","year":"2001"},{"key":"e_1_2_7_3_2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.5858\/2002-126-0499-LDOD","article-title":"Laboratory diagnosis of dysfibrinogenemia","volume":"126","author":"Cunningham MT","year":"2002","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_7_4_2","first-page":"175","volume-title":"Disorders of Hemostasis and Thrombosis: A Clinical Guide","author":"Goodnight SH","year":"2001"},{"key":"e_1_2_7_5_2","first-page":"203","volume-title":"Hemostasis and Thrombosis: Basic Principles and Clinical Practice","author":"Hantagan RR","year":"2001"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(200003)63:3<149::AID-AJH8>3.0.CO;2-#"},{"key":"e_1_2_7_7_2","first-page":"451","article-title":"Studies on a procoagulant fraction of southern copperhead snake venom: the preferential release of fibrinopeptide B","volume":"76","author":"Herzig RH","year":"1970","journal-title":"J Lab Clin Med"},{"key":"e_1_2_7_8_2","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1160\/TH03-01-0004","article-title":"Comparison of PFA\u2010100 testing and bleeding time for detecting platelet hypofunction and von Willebrand disease in clinical practice","volume":"90","author":"Posan E","year":"2003","journal-title":"Thromb Haemost"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.3.661"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.9.4946"},{"key":"e_1_2_7_11_2","first-page":"176","article-title":"Inherited fibrinogen abnormality causing thrombophilia","volume":"17","author":"Egberg O","year":"1967","journal-title":"Thromb Diath Haemorrh"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1986.tb00829.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107678"},{"key":"e_1_2_7_14_2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1182\/blood.V78.1.149.149","article-title":"Fibrinogen Kyoto II, a new congenitally abnormal molecule, characterized by the replacement of A\u03b1 proline\u201018 by leucine","volume":"78","author":"Yoshida N","year":"1991","journal-title":"Blood"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(82)90107-4"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2516.2006.01300.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2516.2006.01300.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T22:26:05Z","timestamp":1697322365000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2516.2006.01300.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,23]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1111\/j.1365-2516.2006.01300.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2516.2006.01300.x","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,23]]}}}