{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:52:24Z","timestamp":1761540744046},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,8]],"date-time":"2006-12-08T00:00:00Z","timestamp":1165536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold>  We report a haemophilia A boy with high inhibitor titre (170\u2003BU) who experienced five life\u2010threatening bleeding episodes during a one\u2010year period from 9 to 21\u2003months. At the age of 22\u2003months, he received rituximab (375\u2003mg\u2003m<jats:sup>\u22122<\/jats:sup> per dose) at one\u2010 and three\u2010week intervals, three courses each and alternative daily treatment with factor VIII concentrate at doses of 100\u2003units\u2003kg<jats:sup>\u22121<\/jats:sup> for 24\u2003weeks and 50\u2003units\u2003kg<jats:sup>\u22121<\/jats:sup> for the following 28\u2003weeks. Although the pretreatment inhibitor level of 4.5\u2003BU showed an anamnestic response reaching the maximum level of 200\u2003BU at the 9th\u2003week of treatment, it gradually declined to 30 BU at the 22nd\u2003week and was constantly maintained at 25\u201330\u2003BU for the following 30\u2003weeks. Only three bleeding episodes of two haematomas and one haemarthrosis were found during the one\u2010year treatment period. No opportunistic infection occured during this period.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2006.01407.x","type":"journal-article","created":{"date-parts":[[2006,12,8]],"date-time":"2006-12-08T12:32:28Z","timestamp":1165581148000},"page":"108-110","source":"Crossref","is-referenced-by-count":8,"title":["Rituximab as an adjuvant therapy to immune tolerance in a haemophilia A boy with high inhibitor titre"],"prefix":"10.1111","volume":"13","author":[{"given":"A.","family":"CHUANSUMRIT","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"HUSAPADOL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"WONGWERAWATTANAKOON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"HONGENG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"SIRACHAINAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"PAKAKASAMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,12,21]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703551"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04916.x"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01185.x"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01060.x"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.8.2153"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2516.2006.01407.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2516.2006.01407.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T02:10:06Z","timestamp":1697335806000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2516.2006.01407.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,21]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1365-2516.2006.01407.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2516.2006.01407.x","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,21]]}}}