{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:51:45Z","timestamp":1790175105221,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2007,12,21]],"date-time":"2007-12-21T00:00:00Z","timestamp":1198195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> The synthetic vasopressin analogue (1\u2013deamino\u20108\u2010<jats:sc>d<\/jats:sc>\u2010arginine\u2010vasopressin) increases plasma concentration of factor VIII and von Willebrand factor in normal subjects and patients with mild haemophilia A and von Willebrand disease. Since its first clinical use in 1977, desmopressin has become the treatment of choice for patients with haemophilia A and factor VIII coagulant activity (FVIII:C) &gt; 5% and has spared several patients the risk of acquiring blood\u2010borne viral infections due to the use of non\u2010virally inactivated plasma\u2010derived FVIII concentrates. An average two to sixfolds FVIII:C increase is typically observed in most patients and return to baseline occurs usually within 8 hours. Several clinical studies have demonstrated the clinical efficacy and safety of desmopressin and the availability of concentrated formulation for subcutaneous injection and of a nasal spray has paved the way to home\u2010treatment. However, overall it appears that haemophilic children may have a lower rate of biologic response compared to adults and a minority of adult patients are not able to attain clinically useful FVIII:C levels post\u2010desmopressin administration. Thus, in every patient with haemophilia A likely to be treated or candidate to an elective invasive procedure, a test\u2010infusion\/injection should be carried out to assess the future usefulness of the compound.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2007.01606.x","type":"journal-article","created":{"date-parts":[[2010,9,15]],"date-time":"2010-09-15T13:16:18Z","timestamp":1284556578000},"page":"15-20","source":"Crossref","is-referenced-by-count":40,"title":["Desmopressin for the treatment of haemophilia"],"prefix":"10.1111","volume":"14","author":[{"given":"G.","family":"CASTAMAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,21]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"19","article-title":"Desmopressin (DDAVP) for treatment of disorders of hemostasis","volume":"8","author":"Mannucci PM","year":"1986","journal-title":"Prog Hemost 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