{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T21:51:32Z","timestamp":1763070692971},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,4,28]],"date-time":"2011-04-28T00:00:00Z","timestamp":1303948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> Total knee arthroplasty (TKA) is a major orthopaedic surgery intervention, indicated for severe haemophilic arthropathy. The aim of our study was to analyse rehabilitation outcome in haemophilic patients after TKA. A consecutive series of 21 patients (23 knees) was retrospectively evaluated. The mean age was 37\u2003\u00b1\u20038\u2003years (range 22\u201355). Physiotherapy treatment was performed twice a day for 5\u2003days\u2003week<jats:sup>\u22121<\/jats:sup>, for 3\u2003h\u2003day<jats:sup>\u22121<\/jats:sup>. Assessment included knee range of motion (ROM), Visual Analogue Scale (VAS) for pain evaluation, Western Ontario and McMaster University (WOMAC) Score for functional outcome, Medical Research Council Scale (MRC) for quadriceps muscle strength evaluation, incidence of adverse events and a self\u2010reported questionnaire. The patients\u2019data were recorded before surgery (t0), at Rehabilitation Unit admission (t1), before discharge (t2) and at follow\u2010up (t3), 11\u201348\u2003months after rehabilitation. Western Ontario and McMaster University Score (ref. score: 0\u201396) was 56.7\u2003\u00b1\u200312 at t0 and 6.2\u2003\u00b1\u20036 at t3 (t3 vs. t0: <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Visual Analogue Scale (ref. score: 0\u201310) decreased from 5.0\u2003\u00b1\u20032 at t1 to 2.1\u2003\u00b1\u20032 at t2 (t2 vs. t1: <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) and to 0.1\u2003\u00b1\u20030 at t3 (t3 vs. t2: <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Flexion degrees increased from 43.4\u2003\u00b1\u200321\u00b0 at t1 to 80.2\u2003\u00b1\u200315\u00b0 at t2 (t2 vs. t1: <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) and to 95.0\u2003\u00b1\u200315\u00b0 at t3 (t3 vs t2: <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). According to MRC (ref. score: 0\u20135), quadriceps muscle strength increased from 2.3\u2003\u00b1\u20030.6 at t1 to 3.6\u2003\u00b1\u20030.5 at t2 (t2 vs. t1: <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Adverse events were found in four patients. Patients\u2019 satisfaction on their outcome at follow\u2010up was referred as good by 72% of patients or excellent by 28% of patients. Postsurgical intensive rehabilitation in haemophilic patients resulted effective, safe and feasible.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2011.02547.x","type":"journal-article","created":{"date-parts":[[2011,4,29]],"date-time":"2011-04-29T02:42:47Z","timestamp":1304044967000},"source":"Crossref","is-referenced-by-count":15,"title":["In\u2010patient rehabilitation in haemophilic subjects with total knee arthroplasty"],"prefix":"10.1111","volume":"17","author":[{"given":"T.","family":"VILIANI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"ZAMBELAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"PANDOLFI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"MARTINI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"MORFINI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"PASQUETTI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"INNOCENTI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4,28]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1055\/s-0037-1613540","article-title":"Orthopaedic surgery in persons with haemophilia","volume":"89","author":"Rodriguez\u2010Merchand EC","year":"2003","journal-title":"Thromb Haemost"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00976.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01553.x"},{"key":"e_1_2_7_5_2","unstructured":"NIH Consensus Development Conference on Total Knee ArthroplastyNational Institutes of Health Consensus Development Conference Statement. 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