{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:52:37Z","timestamp":1790175157397,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,6,9]],"date-time":"2011-06-09T00:00:00Z","timestamp":1307577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> This study was conducted to understand the pathogenetic mechanisms that are involved in the development of bone loss in children with severe haemophilia A (HA). Fourty\u2010four children with severe HA and 40 age\u2010 and gender\u2010matched healthy control subjects were enrolled in this study. Markers of bone remodelling and osteoclast regulation including serum bone specific alkaline phosphatase, parathormone, 25\u2010hydroxy\u2010vitamin D<jats:sub>3<\/jats:sub> (25HOvitD<jats:sub>3<\/jats:sub>), osteocalcin and calcitonin levels were studied. Bone mineral density (BMD) was also studied in all children. The measurement of markers of bone remodelling and osteoclast regulation suggested increased osteoclast\u2010mediated resorption activity in children with severe HA. Although serum parathormone levels were significantly increased, serum 25HOvitD<jats:sub>3<\/jats:sub> and osteocalcin levels were significantly reduced. BMD was significantly reduced in severe haemophilics compared with healthy controls. There was also significant inverse correlation between BMD <jats:italic>z<\/jats:italic>\u2010score and total joint scores, and insignificant inverse correlation between BMD <jats:italic>z<\/jats:italic>\u2010score and single joint scores. There were also significant inverse correlation between 25HOvitD<jats:sub>3<\/jats:sub> and osteocalcin levels and total joint scores. Children with severe HA could have significantly reduced BMD, compared with gender\u2010 and age\u2010matched healthy control subjects. Our results of the markers of bone remodelling and osteoclast regulation suggested that increased osteoclast\u2010mediated resorption and decreased osteoblastic activity in children with severe HA. All children with severe HA should be routinely screened in terms of BMD.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2011.02587.x","type":"journal-article","created":{"date-parts":[[2011,6,9]],"date-time":"2011-06-09T12:51:48Z","timestamp":1307623908000},"page":"69-74","source":"Crossref","is-referenced-by-count":40,"title":["Evaluation of bone mineral density in Turkish children with severe haemophilia A: Ankara hospital 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