{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T14:30:08Z","timestamp":1771943408105,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,6,20]],"date-time":"2011-06-20T00:00:00Z","timestamp":1308528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p><jats:bold>Summary.\u2002<\/jats:bold> To describe the study design, procedures and baseline characteristics of the Haemophilia Utilization Group Study \u2013 Part Va (HUGS Va), a US multi\u2010center observational study evaluating the cost of care and burden of illness in persons with factor VIII deficiency. Patients with factor VIII level \u226430%, age 2\u201364\u2003years, receiving treatment at one of six federally supported haemophilia treatment centres (HTCs) were enrolled in the study. Participants completed an initial interview including questions on socio\u2010demographical characteristics, health insurance status, co\u2010morbidities, access to care, haemophilia treatment regimen, factor utilization, self\u2010reported joint pain and motion limitation and health\u2010related quality of life. A periodic follow\u2010up survey collected data regarding time lost from usual activities, disability days, health care utilization and outcomes of care. HTC clinicians documented participants\u2019 baseline clinical characteristics and pharmacy dispensing records for 2\u2003years. Between July 2005 and July 2007, 329 participants were enrolled. Average age was 9.7\u2003years for children and 33.5\u2003years for adults; two\u2010thirds had severe haemophilia. The distributions of age, marital status, education level and barriers to haemophilia care were relatively consistent across haemophilic severity categories. Differences were found in participants\u2019 employment status, insurance status and income. Overall, children with haemophilia had quality of life scores comparable to healthy counterparts. Adults had significantly lower physical functioning than the general US population. As one of the largest economic studies of haemophilia care, HUGS Va will provide detailed information regarding the burden of illness and health care utilization in the US haemophilia A population.<\/jats:p>","DOI":"10.1111\/j.1365-2516.2011.02595.x","type":"journal-article","created":{"date-parts":[[2011,6,21]],"date-time":"2011-06-21T04:09:20Z","timestamp":1308629360000},"page":"729-736","source":"Crossref","is-referenced-by-count":24,"title":["Haemophilia Utilization Group Study \u2013 Part Va (HUGS Va): design, methods and baseline data"],"prefix":"10.1111","volume":"17","author":[{"given":"Z.\u2010Y.","family":"ZHOU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"WU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"BAKER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"CURTIS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"FORSBERG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"HUSZTI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"KOERPER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"LOU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"MILLER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"PARISH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"RISKE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"SHAPIRO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"ULLMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"JOHNSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,6,20]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00581.x"},{"key":"e_1_2_7_3_2","unstructured":"World Federation of Hemophilia. Available athttp:\/\/www.wfh.org. Accessed July 10 2010."},{"key":"e_1_2_7_4_2","unstructured":"The Centers for Disease Control and Prevention: Hemophilia Data and Statistics. Available athttp:\/\/www.cdc.gov\/ncbddd\/hemophilia\/data.html. 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